DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNMA1 and slo

DIOPT Version :9

Sequence 1:XP_016871696.1 Gene:KCNMA1 / 3778 HGNCID:6284 Length:1311 Species:Homo sapiens
Sequence 2:NP_001262924.1 Gene:slo / 42940 FlyBaseID:FBgn0003429 Length:1217 Species:Drosophila melanogaster


Alignment Length:1250 Identity:656/1250 - (52%)
Similarity:804/1250 - (64%) Gaps:179/1250 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    85 RMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKGRKPRLQGGVIGCMFHLQPREAQ 149
            |.:|.||.||:.||..||.::||||...:   |||.       ::|           .|.|.:.:
  Fly    30 RKYWCFLLSSIFTFLAGLLVVLLWRAFAF---VCCR-------KEP-----------DLGPNDPK 73

Human   150 KSSSALEVHKKYGDSTGTTLEEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMI 214
                                ::.||.:....:.:||                :||..|||||.:|
  Fly    74 --------------------QKEQKASRNKQEFEGT----------------FMTEAKDWAGELI 102

Human   215 SAQTLTGRVLVVLVFALSIGALVIYFID-SSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFI 278
            |.||.|||:||||||.|||.:|:|||:| ||..:|.||.:..:.|.|||:|||:||::||.:|||
  Fly   103 SGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFI 167

Human   279 AANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIK 343
            ||:|||||.||:.|.||:||:||.|||:||:|:|:||||||||||:...:|||:||:||||:||:
  Fly   168 AASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIR 232

Human   344 LVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTL 408
            |..|:|||||.||||||.|||:||||||.: |.|...|:||.|||.|:||||||||||||.:|.|
  Fly   233 LAQLVSIFISVWLTAAGIIHLLENSGDPLD-FNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVL 296

Human   409 GRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFL 473
            ||.|:|||:|.|||:|||::|||.||...|.||||:||....::|||||||||.||||:||||||
  Fly   297 GRTFLVFFLLVGLAVFASWIPEITELAAQRSKYGGTYSKDPRKRHIVVCGHITYESVSHFLKDFL 361

Human   474 HKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKY 538
            |:||:||:||:||||...|:||||.|.|||:|.|.|:||:::|..||.|||:..|||||:|||||
  Fly   362 HEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVAFFQGTMMNAVDLERVKVHEADACLVLANKY 426

Human   539 CADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFI 603
            |.|||||||:|||||||||||...||:|.|::||||||:|||||||:||:|||.|||||||||||
  Fly   427 CQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFI 491

Human   604 AQSCLAQGLSTMLANLFSMRSFIKIEEDT--WQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELC 666
            ||||||.|.|||:||||:|||| |...||  ||..||:|...|||||.||.:|.|::||...|||
  Fly   492 AQSCLAPGFSTMMANLFAMRSF-KTSPDTQAWQNDYLQGTGCEMYTETLSPSFTGMTFPQASELC 555

Human   667 FVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDD 731
            |.|||||::|||.|.|  |..:..:|.||| ...|||..|.|||||..|.|||||:|||||||:|
  Fly   556 FSKLKLLLLAIEIKGA--EEGADSKISINP-RGAKIQANTQGFFIAQSADEVKRAWFYCKACHED 617

Human   732 ITDPKRIKKCGCKR-----------------------------------PKMSIYKRMRRACCFD 761
            |.|...||||.||.                                   |::.....:|.:...|
  Fly   618 IKDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTMEDEHHPAPTFTPPELPKRVHVRGSVSGD 682

Human   762 CGRSERDCSCMSGRVR---------------GNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPST 811
            ..|...|.:.::..||               .|......|...:...||....:.......:...
  Fly   683 ITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQV 747

Human   812 LSPKKKQRNGGMRNSPNTSPKLMRHDPLLIP----------------------GNDQIDNMD--S 852
            :||.:..|......:|....:|......|:|                      .:||..:.|  .
  Fly   748 ISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFEK 812

Human   853 NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNF 917
            ...||||||||||...|.:|..||.|::||||||:||||||:|.|..|.||||||||||||||||
  Fly   813 TEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNF 877

Human   918 HYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNID 982
            |||||||:|.|||::|::|||:.|.|.||:|:|.|:|||||||||||:||||||.||||...:.|
  Fly   878 HYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSND 942

Human   983 DTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNI 1047
            |.:|.|||.||||||||:|.|||:||||......|.    :.|:...||:  :|::.....|.|:
  Fly   943 DPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFD----NLSATAGSPI--VLQRRGSVYGANV 1001

Human  1048 PIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA 1112
            |                           ||||||||:||||||||||||||||||||||||||||
  Fly  1002 P---------------------------MITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTA 1039

Human  1113 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQ 1177
            |||||||||||.||||.|.|||||:|:|||||||||.::||...|||||||.::|:|||||||.|
  Fly  1040 FAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQ 1104

Human  1178 LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQC---TKRYVITNPPYEF 1239
            ::|.|||.|..|:.|.|||||..|||:|.|||.|:||.||    |.|.|   :|||||||||.:|
  Fly  1105 ISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRD----TSSSCDASSKRYVITNPPDDF 1165

Human  1240 ELVPTDLIFCLMQFD 1254
            .|:|||.:|.|||||
  Fly  1166 SLLPTDQVFVLMQFD 1180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNMA1XP_016871696.1 None
sloNP_001262924.1 Ion_trans 110..321 CDD:395416 139/211 (66%)
BK_channel_a 470..566 CDD:397526 65/96 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 551 1.000 Domainoid score I249
eggNOG 1 0.900 - - E1_KOG1420
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1693
Inparanoid 1 1.050 1237 1.000 Inparanoid score I185
Isobase 1 0.950 - 0 Normalized mean entropy S2986
OMA 1 1.010 - - QHG53496
OrthoDB 1 1.010 - - D124461at2759
OrthoFinder 1 1.000 - - FOG0003516
OrthoInspector 1 1.000 - - oto89356
orthoMCL 1 0.900 - - OOG6_101271
Panther 1 1.100 - - LDO PTHR10027
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5164
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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