Protein Alignment KCNMA1 and slo

DIOPT Version :10

• Sequence 1: XP_016871696.1
• Gene: KCNMA1 / 3778
• HGNCID: 6284
• Length: 1311
• Species: Homo sapiens
• Sequence 2: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Alignment Length: 1250
• Identity: 656/1250 - (52%)
• Similarity: 804/1250 - (64%)
• Gaps: 179/1250 - (14%)

Human    85 RMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKGRKPRLQGGVIGCMFHLQPREAQ 149
            |.:|.||.||:.||..||.::||||...:   |||.       ::|           .|.|.:.:
  Fly    30 RKYWCFLLSSIFTFLAGLLVVLLWRAFAF---VCCR-------KEP-----------DLGPNDPK 73

Human   150 KSSSALEVHKKYGDSTGTTLEEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMI 214
                                ::.||.:....:.:||                :||..|||||.:|
  Fly    74 --------------------QKEQKASRNKQEFEGT----------------FMTEAKDWAGELI 102

Human   215 SAQTLTGRVLVVLVFALSIGALVIYFID-SSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFI 278
            |.||.|||:||||||.|||.:|:|||:| ||..:|.||.:..:.|.|||:|||:||::||.:|||
  Fly   103 SGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFI 167

Human   279 AANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIK 343
            ||:|||||.||:.|.||:||:||.|||:||:|:|:||||||||||:...:|||:||:||||:||:
  Fly   168 AASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIR 232

Human   344 LVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTL 408
            |..|:|||||.||||||.|||:||||||.: |.|...|:||.|||.|:||||||||||||.:|.|
  Fly   233 LAQLVSIFISVWLTAAGIIHLLENSGDPLD-FNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVL 296

Human   409 GRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFL 473
            ||.|:|||:|.|||:|||::|||.||...|.||||:||....::|||||||||.||||:||||||
  Fly   297 GRTFLVFFLLVGLAVFASWIPEITELAAQRSKYGGTYSKDPRKRHIVVCGHITYESVSHFLKDFL 361

Human   474 HKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKY 538
            |:||:||:||:||||...|:||||.|.|||:|.|.|:||:::|..||.|||:..|||||:|||||
  Fly   362 HEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVAFFQGTMMNAVDLERVKVHEADACLVLANKY 426

Human   539 CADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFI 603
            |.|||||||:|||||||||||...||:|.|::||||||:|||||||:||:|||.|||||||||||
  Fly   427 CQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFI 491

Human   604 AQSCLAQGLSTMLANLFSMRSFIKIEEDT--WQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELC 666
            ||||||.|.|||:||||:|||| |...||  ||..||:|...|||||.||.:|.|::||...|||
  Fly   492 AQSCLAPGFSTMMANLFAMRSF-KTSPDTQAWQNDYLQGTGCEMYTETLSPSFTGMTFPQASELC 555

Human   667 FVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDD 731
            |.|||||::|||.|.|  |..:..:|.||| ...|||..|.|||||..|.|||||:|||||||:|
  Fly   556 FSKLKLLLLAIEIKGA--EEGADSKISINP-RGAKIQANTQGFFIAQSADEVKRAWFYCKACHED 617

Human   732 ITDPKRIKKCGCKR-----------------------------------PKMSIYKRMRRACCFD 761
            |.|...||||.||.                                   |::.....:|.:...|
  Fly   618 IKDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTMEDEHHPAPTFTPPELPKRVHVRGSVSGD 682

Human   762 CGRSERDCSCMSGRVR---------------GNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPST 811
            ..|...|.:.::..||               .|......|...:...||....:.......:...
  Fly   683 ITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQV 747

Human   812 LSPKKKQRNGGMRNSPNTSPKLMRHDPLLIP----------------------GNDQIDNMD--S 852
            :||.:..|......:|....:|......|:|                      .:||..:.|  .
  Fly   748 ISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFEK 812

Human   853 NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNF 917
            ...||||||||||...|.:|..||.|::||||||:||||||:|.|..|.||||||||||||||||
  Fly   813 TEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNF 877

Human   918 HYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNID 982
            |||||||:|.|||::|::|||:.|.|.||:|:|.|:|||||||||||:||||||.||||...:.|
  Fly   878 HYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSND 942

Human   983 DTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNI 1047
            |.:|.|||.||||||||:|.|||:||||......|.    :.|:...||:  :|::.....|.|:
  Fly   943 DPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFD----NLSATAGSPI--VLQRRGSVYGANV 1001

Human  1048 PIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA 1112
            |                           ||||||||:||||||||||||||||||||||||||||
  Fly  1002 P---------------------------MITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTA 1039

Human  1113 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQ 1177
            |||||||||||.||||.|.|||||:|:|||||||||.::||...|||||||.::|:|||||||.|
  Fly  1040 FAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQ 1104

Human  1178 LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQC---TKRYVITNPPYEF 1239
            ::|.|||.|..|:.|.|||||..|||:|.|||.|:||.||    |.|.|   :|||||||||.:|
  Fly  1105 ISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRD----TSSSCDASSKRYVITNPPDDF 1165

Human  1240 ELVPTDLIFCLMQFD 1254
            .|:|||.:|.|||||
  Fly  1166 SLLPTDQVFVLMQFD 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNMA1	XP_016871696.1	Ion_trans	223..440	CDD:459842	141/217 (65%)
		TrkA	387..>567	CDD:440335	123/179 (69%)
		BK_channel_a	590..677	CDD:460947	59/88 (67%)
slo	NP_001262924.1	Ion_trans	110..321	CDD:459842	139/211 (66%)
		TrkA	261..>504	CDD:440335	169/243 (70%)
		BK_channel_a	478..566	CDD:460947	59/88 (67%)