Protein Alignment KCNMA1 and slo-1

DIOPT Version :10

• Sequence 1: XP_016871696.1
• Gene: KCNMA1 / 3778
• HGNCID: 6284
• Length: 1311
• Species: Homo sapiens
• Sequence 2: NP_001256802.1
• Gene: slo-1 / 180203
• WormBaseID: WBGene00004830
• Length: 1160
• Species: Caenorhabditis elegans
• Alignment Length: 1250
• Identity: 656/1250 - (52%)
• Similarity: 816/1250 - (65%)
• Gaps: 156/1250 - (12%)

Human    54 SSSSSSSVHEP---KMDALIIPVTMEVPCDSR---GQRMWWAFLASSMVTFFGGLFIILLWRTLK 112
            |.|.|...::|   .|:..:..|.||:..:.|   .:|.:|.||.||:.||...:.::::||.:.
 Worm     6 SPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVT 70

Human   113 YLWTVCCHCGGKTKGRKPRLQGGVIGCMFHLQPREAQKSSSALEVHKKYGDSTGTTLEEAQKIN- 176
            :|   ||                        |.||           |::.:.  ....||.:||
 Worm    71 HL---CC------------------------QRRE-----------KEFVEP--IPAPEAVQINM 95

Human   177 NGS----SQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALV 237
            |||    |:.|..||..:||      .:||||..|||||.:||.|:||||.||:|||.||||:|:
 Worm    96 NGSKHAPSETDPFLKQQEEK------HLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLI 154

Human   238 IYFIDSS---NPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTV 299
            |||.|:|   ..:|:|..:....:.|||:.||:|||:||.:|||||:||:||.||:.|.:||||:
 Worm   155 IYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTI 219

Human   300 PPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHL 364
            ||.||::||.|:|||.||||||||:...:|||:|||||||:||:|..|::||::..||.||.:||
 Worm   220 PPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHL 284

Human   365 VENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVP 429
            :|||||.::.|.|...:||.:.||.::||||||||||:|..|..|||||:||||.||||||||||
 Worm   285 LENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVP 349

Human   430 EIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNL 494
            ||.:|||||:||||.|....|:||||||||||.:|||:||:||||:|||||:||:||||.:.|:|
 Worm   350 EIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDL 414

Human   495 ELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNY 559
            |||.|||||||:|||:.|:|::..||:||||..|||||:|||||..:||||||:|||||||||||
 Worm   415 ELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNY 479

Human   560 HPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRS 624
            ...||:|.|::||||||:|||||||:||.|||.|||||||||||||||||.|.|||:||||:|||
 Worm   480 SSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRS 544

Human   625 FIKIEEDT--WQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESR 687
            | |....|  |...||.|...|||||.||.:|..:|||....|.|.:|.||::|||.|.   |..
 Worm   545 F-KTSPHTPLWLNDYLRGAGMEMYTESLSPSFANMSFPEAANLLFNRLGLLLLAIELKD---EEN 605

Human   688 SRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCK-------R 745
            ....|.||||.|:.||..|.|||||..|.|||||||:||.|||||.|...||||.||       .
 Worm   606 KECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRN 670

Human   746 PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFP---------------------- 788
            .|.|...|.:.|...|  .|:.|........|. .|.|::..|
 Worm   671 TKHSTAAREKNAKISD--YSDFDALFYQNDARA-TDVLQQFQPQAPAGPMGHLGQQVQLRMINQQ 732

Human   789 --LSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMD 851
              .|...:|..|..| |:|.::   |.|.    :||.|||.:..|     |...:..:...:...
 Worm   733 SSTSDTHLNTKSLRF-AYEIKK---LMPS----SGGRRNSMSIPP-----DGRGVDFSKDFEQQF 784

Human   852 SNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASN 916
            .:: |||||||||||..:.:|..:|.|.:||||||:||||||:|.|..|.||||||.:||||:||
 Worm   785 QDM-KYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSN 848

Human   917 FHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNI 981
            ||||||||:|.||.:|||::||:||:|.||:|||.|:||||||||||||||||||||:||...|.
 Worm   849 FHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNT 913

Human   982 DDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVN 1046
            :||:|.|||.||||||||:|||||::        ||.|  |...:.|.||
 Worm   914 EDTTLADKEAILASLNIKAMQFDDTL--------GFFP--MRHQTGDRSP--------------- 953

Human  1047 IPIITELAKPGKLPLVSVNQEKNS--GTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFAC 1109
                  |..|     :|: |:|.:  ||::.||||||||:|||||||||||||||||||||||||
 Worm   954 ------LGSP-----ISM-QKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFAC 1006

Human  1110 GTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCR 1174
            |||||:||||||||.|||||:.|||||||||||||||||.::||...||||||||:||:||||||
 Worm  1007 GTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCR 1071

Human  1175 VAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEF 1239
            :||::|.|.|:..:.....||.:|..||:.|..||.|:|||.|.  ..|.. .|||||||||.|.
 Worm  1072 IAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQ--DNPDS-MKRYVITNPPAEL 1133

Human  1240 ELVPTDLIFCLMQFD 1254
            .:..||.::.|.|||
 Worm  1134 RIKNTDYVYVLEQFD 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNMA1	XP_016871696.1	Ion_trans	223..440	CDD:459842	132/219 (60%)
		TrkA	387..>567	CDD:440335	128/179 (72%)
		BK_channel_a	590..677	CDD:460947	53/88 (60%)
slo-1	NP_001256802.1	Ion_trans	139..360	CDD:459842	133/220 (60%)
		TrkA	304..553	CDD:440335	179/249 (72%)
		BK_channel_a	510..584	CDD:460947	48/74 (65%)