Protein Alignment KCNMA1 and kcnma1

DIOPT Version :10

• Sequence 1: XP_016871696.1
• Gene: KCNMA1 / 3778
• HGNCID: 6284
• Length: 1311
• Species: Homo sapiens
• Sequence 2: XP_031761893.1
• Gene: kcnma1 / 100491898
• XenbaseID: XB-GENE-922336
• Length: 1334
• Species: Xenopus tropicalis
• Alignment Length: 1325
• Identity: 1073/1325 - (80%)
• Similarity: 1133/1325 - (85%)
• Gaps: 104/1325 - (7%)

Human    39 SSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLF 103
            :|.|..:|.|:...:..|.|..|.....::|.||||||||||::|.|||||||||||||||||||
 Frog     6 ASQSIFNSMSNIIENPHSKSHPVMASNGESLFIPVTMEVPCDNQGTRMWWAFLASSMVTFFGGLF 70

Human   104 IILLWRTLKYLWTVCCHCGGKTKGRKPRLQGGVIGCMFHLQPREAQKSSSALEVHKKYGDSTGTT 168
            |||:|||.|||||||||||||.|
 Frog    71 IILVWRTFKYLWTVCCHCGGKNK------------------------------------------ 93

Human   169 LEEAQKINNGSSQ--ADGTLKPVDEKEEAVA---AEVGWMTSVKDWAGVMISAQTLTGRVLVVLV 228
              :|||:.|.:|.  .||..|..|:|||..|   .||||||||||||||||||||||||||||.|
 Frog    94 --DAQKVVNAASSQVTDGDYKQTDDKEETAAPGVVEVGWMTSVKDWAGVMISAQTLTGRVLVVTV 156

Human   229 FALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSV 293
            ||||||||:|||||||||||:|||||||||||||||||:||||||||||||||||||||||||||
 Frog   157 FALSIGALMIYFIDSSNPIETCQNFYKDFTLQIDMAFNIFFLLYFGLRFIAANDKLWFWLEVNSV 221

Human   294 VDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTA 358
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
 Frog   222 VDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLCSIFISTWLTA 286

Human   359 AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 423
            ||||||||||||||.||:|:|.|:|||||||||||||||||||||||||||||||||||||||||
 Frog   287 AGFIHLVENSGDPWRNFENSQDLSYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 351

Human   424 FASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLH 488
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   352 FASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLH 416

Human   489 NISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRV 553
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   417 NISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRV 481

Human   554 ISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLAN 618
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   482 ISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLAN 546

Human   619 LFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSAN 683
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||:||..
 Frog   547 LFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPAVCELCFVKLKLLMIAIEFKSEK 611

Human   684 RESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRP-- 746
            .||||||||:||||||:||:||||||||||||||||||||||||||||||||||||||.||||
 Frog   612 GESRSRKRIIINPGNHVKIKEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCACKRPTR 676

Human   747 --------KMSIYKRMRRA--------CCFD------------------CGRSERDCSCMSGRVR 777
                    ::||:.:..:|        .|.:                  |     |.|.:..::.
 Frog   677 EENRLSIHRLSIHPQTAKASYSVASSKLCTEQQEPVPLVNNRKGSLFLPC-----DSSLLHLQLL 736

Human   778 GNVDT-------LERAFPLSS---VSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPK 832
            |:..|       |:||..|..   ...|......:.|||||||.|||||||||||||.|||:||.
 Frog   737 GSSGTEHRTSIKLQRALSLPGKYRYHPNQPVLIQKQFEDEQPSALSPKKKQRNGGMRQSPNSSPN 801

Human   833 LMRHDPLLIPGNDQIDNMD-SNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFG 896
            :|||||||:.||||||||| |:||:||||||||||..||::||:|||||||||||||||||||||
 Frog   802 MMRHDPLLMTGNDQIDNMDSSSVKRYDSTGMFHWCPAKELDKVLLTRSEAAMTVLSGHVVVCIFG 866

Human   897 DVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLR 961
            |::|||||:|||||||||||||||||||||||||::|||||||||||||||||||||||||||||
 Frog   867 DMTSALIGVRNLVMPLRASNFHYHELKHIVFVGSLDYLKREWETLHNFPKVSILPGTPLSRADLR 931

Human   962 AVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSS 1026
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:|||
 Frog   932 AVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGLLQANSQGFTPPGMERSS 996

Human  1027 PDNSPVHGMLRQPSITTGVNIPIITELAKPGK-LPLVSVNQEKNSGTHILMITELVNDTNVQFLD 1090
            ||||||||:.||.|||||.||||||||||||| |||:|.:|||||||||.:|||||||:||||||
 Frog   997 PDNSPVHGVARQASITTGANIPIITELAKPGKLLPLISFSQEKNSGTHIPIITELVNDSNVQFLD 1061

Human  1091 QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN 1155
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1062 QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN 1126

Human  1156 ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHL 1220
            |||||||||||||||||||||||||.||||||||||||||||:||||||||||||||||||||||
 Frog  1127 ALRGGYSTPQTLANRDRCRVAQLALYDGPFADLGDGGCYGDLYCKALKTYNMLCFGIYRLRDAHL 1191

Human  1221 STPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI- 1284
            |||||||||||||||||||||||||||||||||||||.|||||||||||||.|||||||||.||
 Frog  1192 STPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNASQSRASLSHSSHSSHSSSKKSSSVTSIL 1256

Human  1285 -PSTANRQNRPKSRESRDKQNRKEM 1308
             .::||||||.|:|:|||||....|
 Frog  1257 HTASANRQNRVKARDSRDKQKTNRM 1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNMA1	XP_016871696.1	Ion_trans	223..440	CDD:459842	206/216 (95%)
		TrkA	387..>567	CDD:440335	179/179 (100%)
		BK_channel_a	590..677	CDD:460947	85/86 (99%)
kcnma1	XP_031761893.1	Ion_trans	151..368	CDD:459842	206/216 (95%)
		PRK10537	<315..475	CDD:236711	159/159 (100%)
		BK_channel_a	518..605	CDD:460947	85/86 (99%)