Protein Alignment gbb and GDF3

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_065685.1
• Gene: GDF3 / 9573
• HGNCID: 4218
• Length: 364
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 85/289 - (29%)
• Similarity: 139/289 - (48%)
• Gaps: 46/289 - (15%)

  Fly   178 LWFDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTL-GQHTMEP-----LSS 236
            |:|::|.:.....|.:|:|.:....|  .:.....|..:.::.:....: ||.|.:|     |.|
Human   109 LYFNLSAIKEREQLTLAQLGLDLGPN--SYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRS 171

  Fly   237 VNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPF 301
            |...   .|.:..|:.:...:|....:.|.|:::  ..:.:.||     |.|:       .||
Human   172 VPWP---QGAVHFNLLDVAKDWNDNPRKNFGLFL--EILVKEDR-----DSGV-------NFQ-- 217

  Fly   302 MIGFFRGPELIKATAHSSHHRS------KRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLY 360
                   ||...|....|.|.|      .....||.:::::..|  ||.|   .....|....|:
Human   218 -------PEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIP--VPKL---SCKNLCHRHQLF 270

  Fly   361 IDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRL 425
            |:|:|||||.|||||:|:.|.||.|||.|.|...:|::|:|.:|.|:|.::| ::|:..|.||:|
Human   271 INFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDP-EIPQAVCIPTKL 334

  Fly   426 GALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ..:.:||..|::||.|:.|.:|:|..|||
Human   335 SPISMLYQDNNDNVILRHYEDMVVDECGC 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	26/132 (20%)
		TGFB	354..455	CDD:214556	47/101 (47%)
GDF3	NP_065685.1	TGFb_propeptide	<109..220	CDD:279078	27/138 (20%)
		TGFB	264..364	CDD:214556	47/101 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810