Protein Alignment gbb and GDF15

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_004855.2
• Gene: GDF15 / 9518
• HGNCID: 30142
• Length: 308
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 58/245 - (23%)
• Similarity: 92/245 - (37%)
• Gaps: 64/245 - (26%)

  Fly   263 KDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSA 327
            :|::...:.|.||.....||:|...|.:|.::.....|..:     ||  .:..|.:..|...:|
Human    74 EDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGL-----PE--ASRLHRALFRLSPTA 131

  Fly   328 S------HPRKRKKSVSPNNVPLLE---------------------------------------- 346
            |      .|.:|:.|::....|.|.
Human   132 SRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRAR 196

  Fly   347 -------PMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQ 404
                   |:...|.|::.|:....:||||.||:::|.......|.|.|.....|   |..||.::
Human   197 ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIK 258

  Fly   405 TLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            |.:|.|:|..||.|||.|.....: ||....|..|:|:.|.:::.|.|.|
Human   259 TSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	10/41 (24%)
		TGFB	354..455	CDD:214556	35/101 (35%)
GDF15	NP_004855.2	MscS_TM	<23..>147	CDD:331130	18/79 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..177		2/24 (8%)
		TGFB	211..308	CDD:214556	35/101 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810