Protein Alignment gbb and GDF15

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_004855.2
• Gene: GDF15 / 9518
• HGNCID: 30142
• Length: 308
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 58/245 - (23%)
• Similarity: 92/245 - (37%)
• Gaps: 64/245 - (26%)

  Fly   263 KDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSA 327
            :|::...:.|.||.....||:|...|.:|.::.....|..:     ||  .:..|.:..|...:|
Human    74 EDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGL-----PE--ASRLHRALFRLSPTA 131

  Fly   328 S------HPRKRKKSVSPNNVPLLE---------------------------------------- 346
            |      .|.:|:.|::....|.|.
Human   132 SRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRAR 196

  Fly   347 -------PMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQ 404
                   |:...|.|::.|:....:||||.||:::|.......|.|.|.....|   |..||.::
Human   197 ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIK 258

  Fly   405 TLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            |.:|.|:|..||.|||.|.....: ||....|..|:|:.|.:::.|.|.|
Human   259 TSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	10/41 (24%)
		TGF_beta_BMP5_like	353..455	CDD:381639	35/102 (34%)
GDF15	NP_004855.2	PRK10929	<23..>147	CDD:236798	18/79 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..177		2/24 (8%)
		TGF_beta_GDF15	208..307	CDD:381646	35/102 (34%)