Protein Alignment gbb and BMP15

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_005439.2
• Gene: BMP15 / 9210
• HGNCID: 1068
• Length: 392
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 110/468 - (23%)
• Similarity: 173/468 - (36%)
• Gaps: 127/468 - (27%)

  Fly    23 LLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEIL-EFLGIAERPTHLSSHQL 86
            |::|:.......|..||.|            .:|:|...|.:..|:| |..|...|...|..|.|
Human    15 LVLFMEHRAQMAEGGQSSI------------ALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSL 67

  Fly    87 SLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAID 151
                   :::|::|                        |||||   ..|..::|       |.|.
Human    68 -------RYMLELY------------------------RRSAD---SHGHPREN-------RTIG 91

  Fly   152 ESDIIMTFLNKRHHNVDELRHE---HGRRLWFDVSNVPNDN-YLVMAELRIYQNANEGKWLTANR 212
            .:   |..|.|...||.. .|.   |.:.|.|.:.  ||.. |.::....:|::..:   ||
Human    92 AT---MVRLVKPLTNVAR-PHRGTWHIQILGFPLR--PNRGLYQLVRATVVYRHHLQ---LT--- 144

  Fly   213 EFTITVYAIGTGTLGQHTMEPLSSVNTTGDYV--------------GWLELNVTEGLHE--WLVK 261
            .|.::.:           :||....|.|..:.              .|.|:::|:.:.:  |..|
Human   145 RFNLSCH-----------VEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNK 198

  Fly   262 -------------SKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKV-DDEFQP-FMIGFFRGPEL 311
                         .||:.|:.:. |..:..|....|......|:.: ..:|.| .|..|.....|
Human   199 GHRILRLRFMCQQQKDSGGLELW-HGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESL 262

  Fly   312 IKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPE 376
            ::.|..:....::.:||    ..|...|.|          ..|.:....|.|:.|||..|||||.
Human   263 LRRTRQADGISAEVTAS----SSKHSGPEN----------NQCSLHPFQISFRQLGWDHWIIAPP 313

  Fly   377 GYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNL 441
            .|...||.|.|...|...:|:.||||:|.|::.|..:.||:|.|.|.:...:.||....:.::..
Human   314 FYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILY 378

  Fly   442 KKYRNMIVKSCGC 454
            |:|..||.:||.|
Human   379 KEYEGMIAESCTC 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	57/296 (19%)
		TGFB	354..455	CDD:214556	39/101 (39%)
BMP15	NP_005439.2	TGF_beta	291..391	CDD:306518	38/99 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810