Protein Alignment gbb and INHBE

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_113667.1
• Gene: INHBE / 83729
• HGNCID: 24029
• Length: 350
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 98/372 - (26%)
• Similarity: 152/372 - (40%)
• Gaps: 78/372 - (20%)

  Fly    92 APKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDII 156
            |.:.:||..| :|:...::.........|..|..:...:....||:..:|.|..|..:...|  :
Human    47 AKQQILDGLH-LTSRPRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDSTSAYSS--L 108

  Fly   157 MTFLNKRHHNVDELRHEHGRRLWFDV-SNVPNDNYLVMAELRIY----QNANEG-KWLTANREFT 215
            :||    |.:.....|.:..|||..| ..:|.     ...|||:    :...:| :.|.|....|
Human   109 LTF----HLSTPRSHHLYHARLWLHVLPTLPG-----TLCLRIFRWGPRRRRQGSRTLLAEHHIT 164

  Fly   216 ITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDR 280
                     .||.||: .|.|....|:..|.|:|.:            |...:...:....:|.|
Human   165 ---------NLGWHTL-TLPSSGLRGEKSGVLKLQL------------DCRPLEGNSTVTGQPRR 207

  Fly   281 EVKLDDIGLIHRKVDDEFQPFMIGFFRGPEL-IKATAHSSHHRSKRSASHPRKRKKSVSPNNVPL 344
              .||..|  |:      |||:       || |:|        ::..|...|:|        .|.
Human   208 --LLDTAG--HQ------QPFL-------ELKIRA--------NEPGAGRARRR--------TPT 239

  Fly   345 LEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGEC--NFPLNAHMNATNHAIVQTLV 407
            .||  :|..|..:..|:||::|||.|||:.||||...||||:|  :...:..:.|:.|:.|.:|:
Human   240 CEP--ATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLL 302

  Fly   408 HLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ....|......||.||....|.:||..::.||......:|:|::|||
Human   303 KANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	49/218 (22%)
		TGF_beta_BMP5_like	353..455	CDD:381639	38/104 (37%)
INHBE	NP_113667.1	TGF_beta_INHBC_E	247..350	CDD:381676	38/103 (37%)