Protein Alignment gbb and GDF5

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_000548.2
• Gene: GDF5 / 8200
• HGNCID: 4220
• Length: 501
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 110/408 - (26%)
• Similarity: 175/408 - (42%)
• Gaps: 100/408 - (24%)

  Fly    77 RPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNF 141
            ||..::.|:         ::|.:|..      |||.|     .:|..|  |..||........:|
Human   163 RPPPITPHE---------YMLSLYRT------LSDAD-----RKGGNS--SVKLEAGLANTITSF 205

  Fly   142 ITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQNANEGK 206
            |   ||...|...::                 ..:|..||:|.:..|. |:.|||||
Human   206 I---DKGQDDRGPVV-----------------RKQRYVFDISALEKDG-LLGAELRI-------- 241

  Fly   207 WLTANREFTITVYAIGTGTLGQHTM-------EPLSSVNTTG----DYVGWLELNVTEGLHEWLV 260
             |......|....|.|.|...|..:       :|.:.::...    |..||...::      |.:
Human   242 -LRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDI------WKL 299

  Fly   261 --KSKDNHGIYIGAHAVNRPDREVKLDDIGL--IHRKVDDEFQPFMIGFFRGPEL----IKATAH 317
              ..|::..:.:...|..| .|.|.|..:|.  ..|:|.::....:.|..:..:|    |||.:.
Human   300 FRNFKNSAQLCLELEAWER-GRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSG 363

  Fly   318 S----------SHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRS-CQMQTLYIDFKDLGWHDW 371
            .          |..|.:|:....|:.|:           |.::.:: |..:.|:::|||:||.||
Human   364 QDDKTVYEYLFSQRRKRRAPLATRQGKR-----------PSKNLKARCSRKALHVNFKDMGWDDW 417

  Fly   372 IIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLND 436
            ||||..|.||:|.|.|.|||.:|:..||||::|||::.::|:..|..||.||||..:.:|:..:.
Human   418 IIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSA 482

  Fly   437 ENVNLKKYRNMIVKSCGC 454
            .||..|:|.:|:|:||||
Human   483 NNVVYKQYEDMVVESCGC 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	50/242 (21%)
		TGFB	354..455	CDD:214556	49/101 (49%)
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..169		2/5 (40%)
		TGFb_propeptide	145..344	CDD:279078	50/239 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..265		5/18 (28%)
		TGFB	400..501	CDD:214556	49/101 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810