Protein Alignment gbb and LEFTY2

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_003231.2
• Gene: LEFTY2 / 7044
• HGNCID: 3122
• Length: 366
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 78/371 - (21%)
• Similarity: 128/371 - (34%)
• Gaps: 126/371 - (33%)

  Fly   150 IDESDI--IMTFLNKRHHNVDELRHEHGRR--------------------------LWFDV-SNV 185
            :|.:|:  ::...:.|...|..||..||.|                          |.|.: ..:
Human    43 LDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRL 107

  Fly   186 PNDNYLVMAELRIYQNA-------NEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDY 243
            |.::.||.|.||::|..       ..|:....:.:..:||..:.....|.:....:.|...:...
Human   108 PPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHE 172

  Fly   244 VGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRG 308
            .||...:|||.::.|              ..::||                            |.
Human   173 SGWKAFDVTEAVNFW--------------QQLSRP----------------------------RQ 195

  Fly   309 PELIKATAHSSHHRSKRSASHPRKRKKSV-SPNNV--PLLE-------------------PM-ES 350
            |.|::.:....|.....|.:|...|..|. :|..:  |.||                   || |.
Human   196 PLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEG 260

  Fly   351 TRSCQMQTLYIDFKDLGW-HDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKK 414
            ||.|: |.:|||.:.:.| .:|::.|.|:.|:.|.|.|..|..|  .|.|.           |..
Human   261 TRCCR-QEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEA--LAFNW-----------PFL 311

  Fly   415 VPKPCCAPTRLGALPVLYHLND------ENVNLKKYRNMIVKSCGC 454
            .|:.|.| :...:||::..:.:      :.|:|.   ||.|:.|.|
Human   312 GPRQCIA-SETASLPMIVSIKEGGRTRPQVVSLP---NMRVQKCSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	31/190 (16%)
		TGFB	354..455	CDD:214556	30/108 (28%)
LEFTY2	NP_003231.2	TGFb_propeptide	<106..214	CDD:307025	24/149 (16%)
		TGF_beta	263..353	CDD:306518	29/107 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810