Protein Alignment gbb and TGFB1

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 112/490 - (22%)
• Similarity: 185/490 - (37%)
• Gaps: 140/490 - (28%)

  Fly     2 SGLRNTSEAVAVLASLGLGMVLLMFVATTP--PAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDV 64
            ||||          .|.|.:.||..:..||  ||     :|:......|..::.|...|    .:
Human     4 SGLR----------LLPLLLPLLWLLVLTPGRPA-----AGLSTCKTIDMELVKRKRIE----AI 49

  Fly    65 SYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSAD 129
            ..:||..|.:|..|:........|    |:.:|.:|:                   ..|.|.:.:
Human    50 RGQILSKLRLASPPSQGEVPPGPL----PEAVLALYN-------------------STRDRVAGE 91

  Fly   130 LEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHNV-DELRHE-HGRRLWFDVSN----VPND 188
            ..|.|.|.:.::..         .::....:.:.|:.: |:.:.. |...::|:.|.    ||..
Human    92 SAEPEPEPEADYYA---------KEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEP 147

  Fly   189 NYLVMAELR-------------IYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTT 240
            ..|..||||             :||..:...|                ..|....:.|
Human   148 VLLSRAELRLLRLKLKVEQHVELYQKYSNNSW----------------RYLSNRLLAP------- 189

  Fly   241 GDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAH-AVNRPDREVKLD-----------DIGLIHRK 293
            .|...||..:||..:.:||.:..:..|..:.|| :.:..|..:::|           |:..||
Human   190 SDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINAGFTTGRRGDLATIH-- 252

  Fly   294 VDDEFQPFMIGFFRGPELIKAT--AHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMEST-RSCQ 355
              ...:||:        |:.||  ..:.|.:|.|       .::::..|..     ..|| ::|.
Human   253 --GMNRPFL--------LLMATPLERAQHLQSSR-------HRRALDTNYC-----FSSTEKNCC 295

  Fly   356 MQTLYIDF-KDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPC 419
            ::.||||| ||||| .||..|:||.|.:|.|.|.:..:..   |.::.|..|.:...|.....||
Human   296 VRQLYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWSLD---TQYSKVLALYNQHNPGASAAPC 356

  Fly   420 CAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            |.|..|..||::|::. ....:::..||||:||.|
Human   357 CVPQALEPLPIVYYVG-RKPKVEQLSNMIVRSCKC 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	51/291 (18%)
		TGFB	354..455	CDD:214556	39/102 (38%)
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:395559	52/302 (17%)
		TGF_beta_TGFB1	293..391	CDD:381654	39/103 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810