DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and BMP6

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001709.1	Gene:	BMP6 / 654	HGNCID:	1073	Length:	513	Species:	Homo sapiens

Alignment Length:	482	Identity:	164/482 - (34%)
Similarity:	242/482 - (50%)	Gaps:	81/482 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHLSSHQL----SLR-- 89
            ||....:.||          .::|.|...:|.::..|||..||:..||..|...|.    :||
Human    56 PPPSPQSSSG----------FLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQ 110

  Fly    90 -------------------KSAPKFLLDVYHRITA---EEGLSDQDEDDDYER------------ 120
                               ||||.|:||:|:.::|   |:|.|:.:....:..
Human   111 EEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPP 175

  Fly   121 ---GHRSRRSADLEEDEGEQQKNFITDL-DKRAIDESDIIMTFLNKRHHNVD-ELRHEHGRRLWF 180
               .|...|.:.|....|....:.:|.. |...::::|::|:|:|...::.: ..|..|.:...|
Human   176 PGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF 240

  Fly   181 DVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTT---GD 242
            ::|.:|....:..||.|||::...|.:  .|:.|.|::|.:...  .||....|..::|.   ..
Human   241 NLSQIPEGEVVTAAEFRIYKDCVMGSF--KNQTFLISIYQVLQE--HQHRDSDLFLLDTRVVWAS 301

  Fly   243 YVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFR 307
            ..||||.::|...:.|:|..:.|.|:.:.  .|.|....|.....||:.|....:.||||:.||:
Human   302 EEGWLEFDITATSNLWVVTPQHNMGLQLS--VVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFK 364

  Fly   308 GPELIKATAHSSHHRSKRSASHPRK---RKKSVSPNNVPLLEPMESTRSCQMQT------LYIDF 363
            ..|:        |.|:.||||..|:   |.:|....:|..:.......|.:::|      ||:.|
Human   365 VSEV--------HVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSF 421

  Fly   364 KDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGAL 428
            :||||.||||||:||.|.||.|||:|||||||||||||||||||||:.|:.|||||||||:|.|:
Human   422 QDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAI 486

  Fly   429 PVLYHLNDENVNLKKYRNMIVKSCGCH 455
            .|||..::.||.|||||||:|::||||
Human   487 SVLYFDDNSNVILKKYRNMVVRACGCH 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	74/308 (24%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	70/106 (66%)
BMP6	NP_001709.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..66		4/19 (21%)
		TGFb_propeptide	65..362	CDD:279078	75/312 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..131		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..200		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..398		8/24 (33%)
		TGFB	412..513	CDD:214556	69/100 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3724
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3074
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	1	1.000	-	-		otm42011
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4460
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960