Protein Alignment gbb and BMP5

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_066551.1
• Gene: BMP5 / 653
• HGNCID: 1072
• Length: 454
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 159/456 - (34%)
• Similarity: 239/456 - (52%)
• Gaps: 76/456 - (16%)

  Fly    44 DNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEG 108
            ||....:.::|.|...::.::..|||..||:..||...|..:.:  .|||.|:||:|:.:|.||
Human    31 DNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQA--SSAPLFMLDLYNAMTNEE- 92

  Fly   109 LSDQDEDDDYERGHRSRRSADLEEDEGEQ--------------QKNFITDL-----------DKR 148
               ..|:.:|     |.|::..||..|.:              |.:..|.|           |..
Human    93 ---NPEESEY-----SVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTN 149

  Fly   149 AIDESDIIMTFLNKRHHNVDELRHE--HGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTAN 211
            .::::|::|:|:|....:.| ..|:  |.:...||::.:|:...:..||.|||::.:..::  .|
Human   150 FLNDADMVMSFVNLVERDKD-FSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRF--EN 211

  Fly   212 REFTITVYAIGTGTLGQHTMEPLSSVNTTGDY------------VGWLELNVTEGLHEWLVKSKD 264
            ....|::|.|    :.::|       |...|.            ||||..::|...:.|::..::
Human   212 ETIKISIYQI----IKEYT-------NRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQN 265

  Fly   265 NHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELI-----KATAHSSHHRSK 324
            |.|:.:.|...:  .|.:.:...||:.|:.....||||:.||:..|::     .|....:.:|:|
Human   266 NLGLQLCAETGD--GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNK 328

  Fly   325 RSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNF 389
            .|:.....|..||...|.     .|..::|:...||:.|:||||.|||||||||.||||.|||:|
Human   329 SSSHQDSSRMSSVGDYNT-----SEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSF 388

  Fly   390 PLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ||||||||||||||||||||:.|..|||||||||:|.|:.|||..:..||.|||||||:|:||||
Human   389 PLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453

  Fly   455 H 455
            |
Human   454 H 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	71/298 (24%)
		TGF_beta_BMP5_like	353..455	CDD:381639	73/101 (72%)
BMP5	NP_066551.1	TGFb_propeptide	32..304	CDD:459906	71/298 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..343		7/24 (29%)
		TGF_beta_BMP5	342..454	CDD:381665	75/116 (65%)