Protein Alignment gbb and BMP3

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001192.4
• Gene: BMP3 / 651
• HGNCID: 1070
• Length: 472
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 87/357 - (24%)
• Similarity: 156/357 - (43%)
• Gaps: 81/357 - (22%)

  Fly   137 QQKNFITDLD----KRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWF--DVSNV-----PNDNY 190
            |:|:...||.    |.:.::|.::      .|.:||..:.......|.  |::.:     .|:.:
Human   157 QRKHIQIDLSAWTLKFSRNQSQLL------GHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEF 215

  Fly   191 LVMAELRIYQNANEGKWLTANR----EFTITVYAIGTGTLGQHTMEPLSSVNT--------TGDY 243
            |:.     :...::|:.|...|    |..|.|||....     ..||.|.|::        ||..
Human   216 LIG-----FNITSKGRQLPKRRLPFPEPYILVYANDAA-----ISEPESVVSSLQGHRNFPTGTV 270

  Fly   244 VGW-----LELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDRE--VKLDDIGLIHRKVDDEFQPF 301
            ..|     ..|::..       :.|.:.|:.:.......|..|  .|.|::.       :|.:|:
Human   271 PKWDSHIRAALSIER-------RKKRSTGVLLPLQNNELPGAEYQYKKDEVW-------EERKPY 321

  Fly   302 MIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPL--------LEPMESTRSCQMQT 358
                    :.::|.|.......|:....|.::.:::..:...|        :||    |:|..:.
Human   322 --------KTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEP----RNCARRY 374

  Fly   359 LYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLL-EPKKVPKPCCAP 422
            |.:||.|:||.:|||:|:.:.|:||||.|.||:...:..:|||.:|::|..: ....:|:|||.|
Human   375 LKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVP 439

  Fly   423 TRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .::.:|.:|:...::||.||.|.||.|:||.|
Human   440 EKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	37/197 (19%)
		TGFB	354..455	CDD:214556	42/102 (41%)
BMP3	NP_001192.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..53
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..350		5/37 (14%)
		TGF_beta_BMP3	363..472	CDD:381663	45/113 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810