DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and bmp7b

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001070614.2	Gene:	bmp7b / 557567	ZFINID:	ZDB-GENE-060929-328	Length:	427	Species:	Danio rerio

Alignment Length:	464	Identity:	152/464 - (32%)
Similarity:	236/464 - (50%)	Gaps:	58/464 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAER 77
            :::.|.|..::|..|.......:...:...:||....:.:||.|...::.::..|||..||:..|
Zfish     1 MVSLLDLSALVLSLVWGYCVLADTVFTNFTLDNEVHSSFIHRRLKSQERREMQREILSILGLPHR 65

  Fly    78 PTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFI 142
            |   ..|......:||.|:||:|:      .:|.:.:::.:...::...:.........|..||:
Zfish    66 P---RPHLHGKHNAAPMFMLDLYN------AMSTEGDEEGFSYPYKPVFTTQGPPIATLQDNNFL 121

  Fly   143 TDLDKRAIDESDIIMTFLNKRHHNVDELR-HEHGRRLWFDVSNVPNDNYLVMAELRIYQNANEGK 206
            .|        :|::|:|:|...|:.:.|. ..|.|...||:|.:|....:..||.|||::.....
Zfish   122 ND--------ADMVMSFVNLVEHDKEFLPVRRHHREFRFDLSKIPEGEAVTAAEFRIYKDFVPEH 178

  Fly   207 WLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYV------GWLELNVTEGLHEWLVKSKDN 265
            :  .|..|.|::|.:    |.:| ::..|.:......|      |||..::|...:.|::....|
Zfish   179 F--DNETFRISIYQV----LEEH-LDRDSDLFLLDSRVIWAAEEGWLVFDITVTSNHWVLNPGRN 236

  Fly   266 HGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHP 330
            .|:.:...:::  .:.|.....||:.|......||||:.||:..|:        |.||.|||...
Zfish   237 LGLQLALDSLD--GQSVNPWVAGLVGRSGPQSKQPFMVAFFKATEV--------HIRSIRSAQGG 291

  Fly   331 RKRKKSVSPNNVPLLEPMESTR--------------SCQMQTLYIDFKDLGWHDWIIAPEGYGAF 381
            .|::   :||.....:..|:.|              :|:...||:.|:||||.|||||||||.|:
Zfish   292 NKQR---NPNRSKTAKGQEALRVANIAENSSADQKQACKKHELYVSFRDLGWQDWIIAPEGYAAY 353

  Fly   382 YCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRN 446
            ||.|||.||||::||||||||||||||.:.|:.|||||||||:|.|:.|||..:..||.||||||
Zfish   354 YCMGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLHAISVLYFDDSSNVILKKYRN 418

  Fly   447 MIVKSCGCH 455
            |:|::||||
Zfish   419 MVVRACGCH 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	64/267 (24%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	68/100 (68%)
bmp7b	NP_001070614.2	TGFb_propeptide	32..274	CDD:307025	64/267 (24%)
bmp7b	NP_001070614.2	TGF_beta	326..426	CDD:306518	67/99 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3669
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20410
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3143
OMA	1	1.010	-	-		QHG47130
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	1	1.000	-	-		otm25252
orthoMCL	1	0.900	-	-		OOG6_107058
Panther	1	1.100	-	-	LDO	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840