Protein Alignment gbb and bmp4

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001017034.2
• Gene: bmp4 / 549788
• XenbaseID: XB-GENE-483058
• Length: 400
• Species: Xenopus tropicalis
• Alignment Length: 467
• Identity: 126/467 - (26%)
• Similarity: 205/467 - (43%)
• Gaps: 103/467 - (22%)

  Fly    20 GMVLLMFVATTPPAVEATQSGIYI-DNGKDQTIMH----RVLSEDDKL--DVSYEILEFLGIAER 77
            |..:||.:......:..|.....| :.||.:.:..    |..::.::|  |....:|:..|:.:|
 Frog     4 GNRMLMVILLCQVLLGGTNHASLIPETGKKKVVAEIQGGRRSAQSNELLRDFEVTLLQMFGLRKR 68

  Fly    78 PTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFI 142
            |      |.|.....|.::.|:|...:|||    :||..|..
 Frog    69 P------QPSKDVVVPAYMRDLYRLQSAEE----EDELHDIS----------------------- 100

  Fly   143 TDLDKRAIDESDIIMTFLNKRH-HNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIY-QNANEG 205
            .:..:|....::.:.:|.::.| .|:.........|..|::|::|.:..:..||||:| :..:.|
 Frog   101 MEYPERPTSRANTVRSFHHEEHLENLPSTAENGNFRFVFNLSSIPENEVISSAELRLYREQIDHG 165

  Fly   206 -KWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVG--------------WLELNVTEGL 255
             .|......  |.:|.:         |:|:::   :|..:.              |...:|:..:
 Frog   166 PAWEEGFHR--INIYEV---------MKPITA---SGHMISRLLDTRLIHHNVTQWESFDVSPAI 216

  Fly   256 HEWLVKSKDNHGIYIGAHAVNR----PDREVKLDDIGLIHRKVD-DEFQPFMIGFF---RGPELI 312
            ..|....:.|||:.|....:|:    ..:.|::....|.....| .:.:|.:|.|.   ||
 Frog   217 IRWTRDKQINHGLAIEVVHLNQTKTYQGKHVRISRSLLPQEDADWSQMRPLLITFSHDGRG---- 277

  Fly   313 KATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEG 377
                |:...|||||....|.|||:               :.|:..:||:||.|:||:|||:||.|
 Frog   278 ----HALTRRSKRSPKQQRPRKKN---------------KHCRRHSLYVDFSDVGWNDWIVAPPG 323

  Fly   378 YGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLK 442
            |.||||.|:|.|||..|:|:||||||||||:.:. ..:||.||.||.|.|:.:||....:.|.||
 Frog   324 YQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTDLSAISMLYLDEYDKVVLK 387

  Fly   443 KYRNMIVKSCGC 454
            .|:.|:|:.|||
 Frog   388 NYQEMVVEGCGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	53/287 (18%)
		TGF_beta_BMP5_like	353..455	CDD:381639	55/102 (54%)
bmp4	NP_001017034.2	TGFb_propeptide	48..271	CDD:459906	50/269 (19%)
		TGF_beta_SF	294..400	CDD:477357	58/122 (48%)