Protein Alignment gbb and NODAL

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_060525.3
• Gene: NODAL / 4838
• HGNCID: 7865
• Length: 347
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 82/343 - (23%)
• Similarity: 141/343 - (41%)
• Gaps: 68/343 - (19%)

  Fly   141 FITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLW---FDVSNVPNDNYLVMAELRIYQNA 202
            ::..|.:..:..:|||.: |......||      |:. |   ||.|.:.....|..||||:..::
Human    43 YMLSLYRDPLPRADIIRS-LQAEDVAVD------GQN-WTFAFDFSFLSQQEDLAWAELRLQLSS 99

  Fly   203 -----NEGKWL----------------TANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGW 246
                 .||...                :....|.:.::.:   ||.|.|..           :|.
Human   100 PVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTV---TLSQVTFS-----------LGS 150

  Fly   247 LELNVTEGLHEWLVK--SKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGP 309
            :.|.||..|.:||..  :.:.....:......||......:.:.:::..:..|.:..      |.
Human   151 MVLEVTRPLSKWLKHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQL------GG 209

  Fly   310 ELIKATAHSSHHRSKRSAS---HPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDW 371
            ..:...|.||....:...|   ..|.|:     :::|     :.::.|:.....:||..:||..|
Human   210 STLLWEAESSWRAQEGQLSWEWGKRHRR-----HHLP-----DRSQLCRKVKFQVDFNLIGWGSW 264

  Fly   372 IIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLND 436
            ||.|:.|.|:.|.|||..|:....:.||||.:|:|:...:|.:||..||||.:...|.:|| :::
Human   265 IIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLY-VDN 328

  Fly   437 ENVNLKKYRNMIVKSCGC 454
            ..|.|..:::|||:.|||
Human   329 GRVLLDHHKDMIVEECGC 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	34/189 (18%)
		TGFB	354..455	CDD:214556	40/101 (40%)
NODAL	NP_060525.3	TGFb_propeptide	29..166	CDD:279078	31/144 (22%)
		TGFB	247..346	CDD:214556	38/99 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810