Protein Alignment gbb and gdf11

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_998140.1
• Gene: gdf11 / 406247
• ZFINID: ZDB-GENE-040427-2
• Length: 390
• Species: Danio rerio
• Alignment Length: 464
• Identity: 101/464 - (21%)
• Similarity: 175/464 - (37%)
• Gaps: 104/464 - (22%)

  Fly    11 VAVLASLGLGMVLLMFVATTPPAVEATQSGIY---IDNGKDQTIMHRVLSEDDKL----DVSYEI 68
            :.||.||||.......:...|.:..::..|:.   :|:.:.......|..|..|:    .:..:|
Zfish    10 LTVLISLGLSGSDEPNLFLAPLSEMSSDIGVSLFDVDDVESSECSACVWREQSKVLRLETIKSQI 74

  Fly    69 LEFLGIAERPTHLSSHQLS--LRKSAP-KFLLDVYHRITAE-EGLSDQDEDDDYERGHRSRRSAD 129
            |..|.:.:.| ::|...::  |.|:.| :.||| :|....: ..|.|..:.|:|   |.:..|..
Zfish    75 LSKLRLKQAP-NISREVVNQLLPKAPPLQQLLD-HHDFQGDASSLEDFIDADEY---HATTESVI 134

  Fly   130 LEEDEGEQQKNFITDLDKRAI-----DESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDN 189
            ....|.|.    :..:|.:..     ....::.|.:.|             .:||..:..:...:
Zfish   135 TMASEPEP----LVQVDGKPTCCFFKFSPKLMFTKVLK-------------AQLWVYLQPLKQTS 182

  Fly   190 YLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEG 254
            .:.:..||:.....:|     :|...|....|...:...|                |..::....
Zfish   183 TVYLQILRLKPITEQG-----SRHIRIRSLKIELDSQAGH----------------WQSIDFKHV 226

  Fly   255 LHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSS 319
            |..|..:...|.||.|.|:  :....::.:..:|    ..::..|||:     ..::::.|
Zfish   227 LQNWFKQPHTNWGIDINAY--DESGNDLAVTSLG----PGEEGLQPFL-----EVKILETT---- 276

  Fly   320 HHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRS-CQMQTLYIDFKDLGWHDWIIAPEGYGAFYC 383
             .||:|               |:.|.....||.| |....|.:||:..|| ||||||:.|.|.||
Zfish   277 -KRSRR---------------NLGLDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYC 324

  Fly   384 SGECNFPL---NAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYR 445
            ||:|.:..   ..|.:...||         .|:....|||.||::..:.:||..:.:.:...|..
Zfish   325 SGQCEYMFMQKYPHTHLVQHA---------NPRGSAGPCCTPTKMSPINMLYFNDKQQIIHGKIP 380

  Fly   446 NMIVKSCGC 454
            .|:|..|||
Zfish   381 GMVVDRCGC 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	47/272 (17%)
		TGF_beta_BMP5_like	353..455	CDD:381639	37/106 (35%)
gdf11	NP_998140.1	TGFb_propeptide	52..268	CDD:480997	46/264 (17%)
		TGF_beta_GDF8	284..390	CDD:381658	40/116 (34%)