Protein Alignment gbb and tgfb2

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_919366.1
• Gene: tgfb2 / 369194
• ZFINID: ZDB-GENE-030723-3
• Length: 411
• Species: Danio rerio
• Alignment Length: 476
• Identity: 118/476 - (24%)
• Similarity: 196/476 - (41%)
• Gaps: 111/476 - (23%)

  Fly    19 LGMVLLMFVATTPPAVEATQSGIYIDNGKD---QTIMHRVLSEDDKLDVSYEILEFLGIAERPTH 80
            |.::||:.:|....:: :|.|.:.:|..|.   :.|..::||: .||....||.      ..|..
Zfish     6 LSLLLLLDLAAVAVSL-STCSTVDMDQFKKKRIEAIRGQILSK-LKLSSPPEIY------PEPEE 62

  Fly    81 LSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFITDL 145
            :|...:::..|....|                     .|:.:....:.:.:..|.|.....:..:
Zfish    63 VSRGIIAIYNSTRDLL---------------------QEKANERAATCERQRSEEEYYAKEVHKI 106

  Fly   146 DKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNV-PNDNYLVMAELRIYQNANEGKWLT 209
            |.:....|:.::.   .:|:      :.:.|||.||||:: .|.:.||.|:|||::..|....:.
Zfish   107 DMQPFYPSENVIL---SQHY------YPYFRRLMFDVSSMEKNASNLVKAQLRIFRLQNPKARVF 162

  Fly   210 ANREFTITVY-AIGTGTLGQHTMEPLSS----VNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIY 269
            ..|   |.:| .:|...|...|...::|    ..|.|:   ||..:|||.:.|||:....|.|..
Zfish   163 EQR---IELYQVLGHKDLTSPTQRYINSKVVRTRTEGE---WLSFDVTEAVSEWLLHRDRNKGFK 221

  Fly   270 IGAHA------------VNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPEL--IKATAHS-- 318
            |..|.            :.....|::....|     :||       .|..|.:|  .|...||
Zfish   222 ISLHCPCCTFVPSNNYIIPNKSEELETRFAG-----IDD-------SFVNGGDLKMFKKRRHSGQ 274

  Fly   319 ----------SHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQ----MQTLYIDF-KDLGW 368
                      |:....:..||.:||          .|:....:|:.|    :::||||| |||||
Zfish   275 SPHLLLMLLPSYRLESQHKSHRQKR----------ALDTAFCSRNVQDNRCLRSLYIDFKKDLGW 329

  Fly   369 HDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYH 433
            . ||..|:||.|.:|:|.|.:..:|.   |.|:.:..|.:.:.|:....|||....|..|.:||:
Zfish   330 R-WIHEPKGYNANFCAGACPYLWSAD---TQHSNILGLYNTINPEASASPCCVSQDLEPLTILYY 390

  Fly   434 LNDENVNLKKYRNMIVKSCGC 454
            :. :...:::..|||||||.|
Zfish   391 IG-KTPKIEQLSNMIVKSCKC 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	58/280 (21%)
		TGF_beta_BMP5_like	353..455	CDD:381639	40/107 (37%)
tgfb2	NP_919366.1	TGFb_propeptide	21..228	CDD:480997	57/250 (23%)
		TGF_beta_TGFB2	314..410	CDD:381655	38/100 (38%)