DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and Gdf1

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001037705.1	Gene:	Gdf1 / 306351	RGDID:	1304678	Length:	357	Species:	Rattus norvegicus

Alignment Length:	192	Identity:	59/192 - (30%)
Similarity:	87/192 - (45%)	Gaps:	45/192 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 GPELIK-----------------ATAHSSHHRSKR--SASHP-------RKRKKS-----VSPNN 341
            ||||::                 ..|::|..|:.|  .|.||       |..:.|     :.|..
  Rat   165 GPELLRVQAPPGLPLRADLLGTAVAANASVPRTLRLALALHPGAAATCGRLAEASLLLVTLDPRL 229

  Fly   342 VPLLEPMESTR---------SCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAH--- 394
            .||......|.         :|:.:.|::.|:::|||.|:|||.|:.|.:|.|.|..|....
  Rat   230 CPLPRSRRHTEPRVGGGPVGTCRTRRLHVSFREVGWHRWVIAPRGFLANFCQGTCALPETLRGPG 294

  Fly   395 -MNATNHAIVQTLVHLLEPKK-VPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
             ..|.|||:::.|:|...|.. |..|||.|.||..:.||:..|.:||.|:.|.:|:|..|||
  Rat   295 GPPALNHAVLRALMHAAAPTPGVGSPCCVPERLSPISVLFFDNSDNVVLRHYEDMVVDECGC 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	42/106 (40%)
Gdf1	NP_001037705.1	TGFB	251..357	CDD:214556	42/106 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810