Protein Alignment gbb and bmp2a

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_571434.1
• Gene: bmp2a / 30631
• ZFINID: ZDB-GENE-980526-388
• Length: 386
• Species: Danio rerio
• Alignment Length: 471
• Identity: 126/471 - (26%)
• Similarity: 212/471 - (45%)
• Gaps: 114/471 - (24%)

  Fly    11 VAVLASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIA 75
            |:..|:|.:.||..:|.|.:        ||:....|:..      ||.|........:|...|:.
Zfish     2 VSSTAALMVLMVTQVFFAGS--------SGLVPQVGRSS------LSPDVLHAFELRLLSMFGLQ 52

  Fly    76 ERPTHLSSHQLSLRKSAPKFLLDVY--HRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQ 138
            .|||..:|      ...|:::||:|  |.:.||:        ....|.|..:.|
Zfish    53 HRPTPSTS------AVVPQYMLDLYSAHSVNAEQ--------VSRPRAHLGKGS----------- 92

  Fly   139 KNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHG-------RRLWFDVSNVPNDNYLVMAEL 196
                    :|:...::.|.:|    ||  ||...:..       :|..|:::::|::..:..|::
Zfish    93 --------ERSASRANTIRSF----HH--DESTEDPSSSSVRTTQRFLFNLTSIPDEELVTSADV 143

  Fly   197 RIYQNANEGKWLTANREF-TITVYAI--GTGTLGQHTMEPLSSVNTT----GDYVGWLELNVTEG 254
            |:::.........|:..| .|.|:.|  .:|:|    .||::.:..|    .....|...:||..
Zfish   144 RVFREQIVSSLNNASAGFHRINVHEIIRPSGSL----QEPITRLLDTRLVQHSLSKWESFDVTPA 204

  Fly   255 LHEWLVKSKDNHGIYIGAHAVNRPDRE----VKLDDIGLIHRKVD--DEFQPFMIGFFRGPELIK 313
            :.:|......||||.:   .::.||::    |::.  ..:|...|  .:.:|.::.:
Zfish   205 VLKWTTDGHPNHGILV---EISHPDQDSRKHVRVS--RSLHNNEDTWSQMRPLLVTY-------- 256

  Fly   314 ATAHSS-----HHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWII 373
              :|..     |.|.||.|.:.::|||..:              :|:..:||:||.|:||:|||:
Zfish   257 --SHDGKGNVLHSREKRQARNNKQRKKHKA--------------NCRRHSLYVDFSDVGWNDWIV 305

  Fly   374 APEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDEN 438
            ||.||.||||.|||.|||..|:|:|.:|:|||||:.:. ..:|:.||.||.|..:.:||....|.
Zfish   306 APPGYHAFYCQGECPFPLADHLNSTTNAMVQTLVNSVN-SNIPRACCVPTDLSPVSLLYLDEYER 369

  Fly   439 VNLKKYRNMIVKSCGC 454
            |.||.|::|:|:.|||
Zfish   370 VILKNYQDMVVEGCGC 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	56/281 (20%)
		TGF_beta_BMP5_like	353..455	CDD:381639	52/102 (51%)
bmp2a	NP_571434.1	TGFb_propeptide	40..256	CDD:459906	52/263 (20%)
		TGF_beta_BMP2_like	286..386	CDD:381638	52/101 (51%)