DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gbb and bmp7a

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_571396.1	Gene:	bmp7a / 30584	ZFINID:	ZDB-GENE-000208-25	Length:	432	Species:	Danio rerio

Alignment Length:	470	Identity:	159/470 - (33%)
Similarity:	231/470 - (49%)	Gaps:	73/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MVLLMF----VATTPPA------VEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIA 75
            |.|.||    ::|...|      .:|.|:...:||....:.:.|.|...::.::..|||..||:.
Zfish     1 MTLKMFPVHLISTLIVACGCSVLADAMQANFTMDNDIQSSFIQRRLKSQERREMQREILSILGLP 65

  Fly    76 ERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDD----DYERGHRSRRSADLEEDEGE 136
            :||..|...:   ..:||.::||:|:.|     |.|.|...    .||..:.:
Zfish    66 QRPRPLLHER---HTAAPMYMLDLYNAI-----LEDGDRRGGLVYSYEPAYTT------------ 110

  Fly   137 QQKNFITDLDKRAIDESDIIMTFLNKRHHNVD-ELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQ 200
            .....:|..|.|.:.::|::|:|.|......| :|.|:|.|...||:|.:|....:..||.|||:
Zfish   111 PGPPLVTQQDSRFLSDADMVMSFANTVDPEEDLQLYHQHRREFRFDLSRIPPGETVTAAEFRIYK 175

  Fly   201 NANEGKWLTANREFTITVYAIGTGTLGQHTME--PLSSVNTTGDYVGWLELNVTEGLHEWLVKSK 263
            :....::  .|..|.::|:.:   ...||..|  .|.|........|||..::|...:.|::...
Zfish   176 DFVRERY--ENETFHVSVFQV---LQQQHRRELYLLDSRVVWAAEEGWLVFDLTVTSNHWVINPG 235

  Fly   264 DNHGIYI---GAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKR 325
            .|.|:.:   .:|......|..     ||:........||||:.|.:        |...|.||.|
Zfish   236 QNLGLQLLVETSHGARMNPRRA-----GLVGSSGAQNKQPFMVAFLK--------ASGIHLRSVR 287

  Fly   326 SAS-------HPRKRKKSVSPNNVPLLEPMEST--------RSCQMQTLYIDFKDLGWHDWIIAP 375
            |||       |..|..|..:.::...|:..|:|        :.|:...||:.|:||||.||||||
Zfish   288 SASGGKQKGHHRTKNAKPGAAHSQVALKTAEATEGASIDPKQGCKKHELYVSFRDLGWQDWIIAP 352

  Fly   376 EGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVN 440
            |||.|:||.|||.||||::||||||||||||||.:.|:.|||||||||:|..:.|||..:..||.
Zfish   353 EGYAAYYCEGECVFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLHGISVLYFDDSSNVI 417

  Fly   441 LKKYRNMIVKSCGCH 455
            |||||||:|::||||
Zfish   418 LKKYRNMVVRACGCH 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	67/270 (25%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	67/100 (67%)
bmp7a	NP_571396.1	TGFb_propeptide	34..275	CDD:279078	67/270 (25%)
bmp7a	NP_571396.1	TGF_beta	329..431	CDD:278448	66/101 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3669
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3143
OMA	1	1.010	-	-		QHG47130
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	1	1.000	-	-		otm25252
orthoMCL	1	0.900	-	-		OOG6_107058
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840