DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gbb and ndr2

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_624359.1	Gene:	ndr2 / 30292	ZFINID:	ZDB-GENE-990415-181	Length:	501	Species:	Danio rerio

Alignment Length:	172	Identity:	57/172 - (33%)
Similarity:	88/172 - (51%)	Gaps:	19/172 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 DDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLE--P 347
            |...|:|.....:|.     |.|..:.:|      ..|:.||     :|.:...|...|.|:  |
Zfish   346 DGASLLHTAGASKFL-----FSRNKKEVK------RGRALRS-----RRGRRGPPVRSPELQRTP 394

  Fly   348 MESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEP 412
            :..:.:|:...:::||..:||..||:.|:.|.|:.|.|.|..||...:..||||.:|:|:....|
Zfish   395 LHKSTTCRRVDMHVDFNQIGWGSWIVFPKKYNAYRCEGACPNPLGEELRPTNHAYMQSLLKYHHP 459

  Fly   413 KKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .:||..||||||..||.:||:.|.|.: |:.:.:|.|:.|||
Zfish   460 SRVPASCCAPTRTSALSMLYYENGEMI-LRHHEDMQVEECGC 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	4/19 (21%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	42/101 (42%)
ndr2	NP_624359.1	TGFb_propeptide	44..>174	CDD:279078
		DUF1631	<175..>277	CDD:285086
		TGF_beta	401..500	CDD:278448	40/99 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910