Protein Alignment gbb and Nodal

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001099864.1
• Gene: Nodal / 294503
• RGDID: 1305994
• Length: 354
• Species: Rattus norvegicus
• Alignment Length: 357
• Identity: 82/357 - (22%)
• Similarity: 138/357 - (38%)
• Gaps: 113/357 - (31%)

  Fly   148 RAIDESDIIMTFLNKRHHNVDELRHEHGRRLW---FDVSNVPNDNYLVMAELRI-----YQNANE 204
            |::...|:.:|..|                 |   ||.|.:..:..||.||||:     ..:..:
  Rat    60 RSLQAQDVDVTGQN-----------------WTFTFDFSFLSQEEDLVWAELRLQLLSPMDSPTK 107

  Fly   205 GKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLE-----------------LNVT 252
            |       ..||.::........|...:.|..|        |:|                 |.||
  Rat   108 G-------PLTIDIFHQAKPDPEQDPADCLERV--------WMERITVTPSQVTFASDSTVLEVT 157

  Fly   253 EGLHEWLVKSKDNHGI--YIGAHA-----------------------VNRPDREVKLDDIGLIHR 292
            :.|.:||   ||...:  .:.:.|                       .|||..:.:|....|:.
  Rat   158 KPLSKWL---KDPRALEKQVSSQAGKCWHQSHTQPVPVTSTSVLMLYSNRPQEQRQLGGATLLW- 218

  Fly   293 KVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQ 357
            :.:..::                |.......:||....|:|:     :::|     :.::.|:..
  Rat   219 EAESSWR----------------AQEGQLSVERSGWGRRQRR-----HHLP-----DRSQLCRRV 257

  Fly   358 TLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAP 422
            ...:||..:||..|||.|:.|.|:.|.|||..|:....:.||||.:|:|:...:|.:||..||||
  Rat   258 KFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAP 322

  Fly   423 TRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .:...|.:|| :::..|.|:.:::|||:.|||
  Rat   323 VKTKPLSMLY-VDNGRVLLEHHKDMIVEECGC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	36/206 (17%)
		TGF_beta_BMP5_like	353..455	CDD:381639	40/102 (39%)
Nodal	NP_001099864.1	TGF_beta_NODAL	252..353	CDD:381637	38/101 (38%)