Protein Alignment gbb and Lefty2

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001007557.1
• Gene: Lefty2 / 289316
• RGDID: 1359679
• Length: 366
• Species: Rattus norvegicus
• Alignment Length: 440
• Identity: 81/440 - (18%)
• Similarity: 145/440 - (32%)
• Gaps: 175/440 - (39%)

  Fly    60 DKLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRS 124
            |::||.       |:| .|||:||..::|.                      |....|..||.|.
  Rat    44 DRVDVE-------GMA-IPTHVSSQYVALL----------------------QGSHADRSRGKRF 78

  Fly   125 RRSADLEEDEGEQQKNFITDLDKRAIDE--SDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPN 187
                         .:||.....:..:.|  |.:::..:.:|                     :|.
  Rat    79 -------------SQNFREVAGRFLVSETSSHLLVFGMEQR---------------------LPP 109

  Fly   188 DNYLVMAELRIYQNANEGKWLTANR----------EFTITVYAIGTGTLGQHTMEPLSSVNTTGD 242
            ::.||.|.||::|   |....||.|          :..:|:..:.....|.:....:.|...:..
  Rat   110 NSELVQAMLRLFQ---EPVPRTALRRLERLPPHSAQARVTIEWLRVREDGSNRTALIDSRLVSIY 171

  Fly   243 YVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFR 307
            ..||...:|||.::.|              ..::||                            |
  Rat   172 ESGWKVFDVTEAVNFW--------------QQLSRP----------------------------R 194

  Fly   308 GPELIKATAHSSH--------HRSKRSAS--------------HPRKRKKSVSPNNVPLLEPM-E 349
            .|.|::.:....|        |:..|.|:              |....|...:..|.....|: |
  Rat   195 QPLLLQVSVQREHLGPGTWSAHKLVRFAAQGTPDGKGEPQLELHTLDLKDYGAQGNCDPEAPVTE 259

  Fly   350 STRSCQMQTLYIDFKDLGW-HDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLV---HLL 410
            .||.|:.: :|:|.:.:.| .:||:.|.|:..:.|.|.|            ..:.::|.   ..|
  Rat   260 GTRCCRKE-MYLDLQGMKWAENWILEPPGFLIYECVGSC------------RQLPESLTIGWPFL 311

  Fly   411 EPKKVPKPCCAPTRLGALPVLYHLNDEN------VNLKKYRNMIVKSCGC 454
            .|::     |..:.:.:||::..:.::.      |:|.   ||.|::|.|
  Rat   312 GPRQ-----CVASEMTSLPMIVSIKEDGKTRPQVVSLP---NMRVQTCSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	43/256 (17%)
		TGF_beta_BMP5_like	353..455	CDD:381639	24/112 (21%)
Lefty2	NP_001007557.1	TGF-beta propeptide	45..231		49/294 (17%)
		TGFb_propeptide	<106..203	CDD:480997	26/162 (16%)
		TGF_beta_LEFTY1_2	262..353	CDD:381636	24/111 (22%)
		transforming growth factor beta-like domain	263..353		23/110 (21%)