Protein Alignment gbb and GDF10

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_004953.1
• Gene: GDF10 / 2662
• HGNCID: 4215
• Length: 478
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 66/242 - (27%)
• Similarity: 105/242 - (43%)
• Gaps: 58/242 - (23%)

  Fly   232 EPLSSVNTTGD--------YVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAV---------NRPD 279
            ||.::.|.:.|        ..|.|:.|...||.|   :....|..:...|.:         .||.
Human   275 EPRAAPNNSADPRVRRAAQATGPLQDNELPGLDE---RPPRAHAQHFHKHQLWPSPFRALKPRPG 336

  Fly   280 REVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPL 344
            |:.:        ||             :|.|:..|.:.......|......||:
Human   337 RKDR--------RK-------------KGQEVFMAASQVLDFDEKTMQKARRKQ----------- 369

  Fly   345 LEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHL 409
               .:..|.|..:.|.:||.|:||::|||:|:.:.|:||:|.|.||:...:..:|||.:|::|..
Human   370 ---WDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRA 431

  Fly   410 --LEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
              :.| .:|:|||.|.::.:|.||:...:.||.||.|.||.|.:|.|
Human   432 VGIIP-GIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	17/89 (19%)
		TGF_beta_BMP5_like	353..455	CDD:381639	42/104 (40%)
GDF10	NP_004953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..319		11/46 (24%)
		TGF_beta_GDF10	367..478	CDD:381664	45/126 (36%)