Protein Alignment gbb and MSTN

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_005250.1
• Gene: MSTN / 2660
• HGNCID: 4223
• Length: 375
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 109/452 - (24%)
• Similarity: 175/452 - (38%)
• Gaps: 89/452 - (19%)

  Fly    14 LASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMH----RVLSEDDKLD-VSYEILEFLG 73
            :..|.|.:.:.:|:......|:..::....:|.:.:.:.:    |..::..::: :..:||..|.
Human     1 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLR 65

  Fly    74 IAERPTHLSS---HQLSLRKSAP-KFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDE 134
            :...| ::|.   .|| |.|:.| :.|:|.|. :..::......|||||.....:..:...|.|
Human    66 LETAP-NISKDVIRQL-LPKAPPLRELIDQYD-VQRDDSSDGSLEDDDYHATTETIITMPTESD- 126

  Fly   135 GEQQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIY 199
                  |:..:|.:   .......|.:|..:|     .....:||..:..|.....:.:..||:.
Human   127 ------FLMQVDGK---PKCCFFKFSSKIQYN-----KVVKAQLWIYLRPVETPTTVFVQILRLI 177

  Fly   200 QNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKD 264
            :...:|...|..|...:.:.. |||.                    |..::|...|..||.:.:.
Human   178 KPMKDGTRYTGIRSLKLDMNP-GTGI--------------------WQSIDVKTVLQNWLKQPES 221

  Fly   265 NHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASH 329
            |.||.|.|...|..|..|.....|      :|...||:        .:|.|  .:..||:|...
Human   222 NLGIEIKALDENGHDLAVTFPGPG------EDGLNPFL--------EVKVT--DTPKRSRRDFG- 269

  Fly   330 PRKRKKSVSPNNVPLLEPME-STRS-CQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLN 392
                           |:..| ||.| |....|.:||:..|| ||||||:.|.|.||||||.|...
Human   270 ---------------LDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFL 318

  Fly   393 AHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .....|:      |||...|:....|||.||::..:.:||....|.:...|...|:|..|||
Human   319 QKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	55/268 (21%)
		TGF_beta_BMP5_like	353..455	CDD:381639	41/103 (40%)
MSTN	NP_005250.1	TGFb_propeptide	49..253	CDD:480997	52/248 (21%)
		TGF_beta_GDF8	268..375	CDD:381658	45/130 (35%)