Protein Alignment gbb and MSTN

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_005250.1
• Gene: MSTN / 2660
• HGNCID: 4223
• Length: 375
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 109/452 - (24%)
• Similarity: 175/452 - (38%)
• Gaps: 89/452 - (19%)

  Fly    14 LASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMH----RVLSEDDKLD-VSYEILEFLG 73
            :..|.|.:.:.:|:......|:..::....:|.:.:.:.:    |..::..::: :..:||..|.
Human     1 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLR 65

  Fly    74 IAERPTHLSS---HQLSLRKSAP-KFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDE 134
            :...| ::|.   .|| |.|:.| :.|:|.|. :..::......|||||.....:..:...|.|
Human    66 LETAP-NISKDVIRQL-LPKAPPLRELIDQYD-VQRDDSSDGSLEDDDYHATTETIITMPTESD- 126

  Fly   135 GEQQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIY 199
                  |:..:|.:   .......|.:|..:|     .....:||..:..|.....:.:..||:.
Human   127 ------FLMQVDGK---PKCCFFKFSSKIQYN-----KVVKAQLWIYLRPVETPTTVFVQILRLI 177

  Fly   200 QNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKD 264
            :...:|...|..|...:.:.. |||.                    |..::|...|..||.:.:.
Human   178 KPMKDGTRYTGIRSLKLDMNP-GTGI--------------------WQSIDVKTVLQNWLKQPES 221

  Fly   265 NHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASH 329
            |.||.|.|...|..|..|.....|      :|...||:        .:|.|  .:..||:|...
Human   222 NLGIEIKALDENGHDLAVTFPGPG------EDGLNPFL--------EVKVT--DTPKRSRRDFG- 269

  Fly   330 PRKRKKSVSPNNVPLLEPME-STRS-CQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLN 392
                           |:..| ||.| |....|.:||:..|| ||||||:.|.|.||||||.|...
Human   270 ---------------LDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFL 318

  Fly   393 AHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .....|:      |||...|:....|||.||::..:.:||....|.:...|...|:|..|||
Human   319 QKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	55/269 (20%)
		TGFB	354..455	CDD:214556	40/101 (40%)
MSTN	NP_005250.1	TGFb_propeptide	39..249	CDD:279078	52/254 (20%)
		TGFB	281..375	CDD:214556	40/101 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810