Protein Alignment gbb and GDF2

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_057288.1
• Gene: GDF2 / 2658
• HGNCID: 4217
• Length: 429
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 114/467 - (24%)
• Similarity: 176/467 - (37%)
• Gaps: 148/467 - (31%)

  Fly    48 DQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQ 112
            :.|...::..|:.|:|    .|..|.::..|:     |...|...|::::|:|:|.|:
Human    50 EHTFNLKMFLENVKVD----FLRSLNLSGVPS-----QDKTRVEPPQYMIDLYNRYTS------- 98

  Fly   113 DEDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHNV----DELRHE 173
                                             ||.....|:|:.:|..:...::    |....:
Human    99 ---------------------------------DKSTTPASNIVRSFSMEDAISITATEDFPFQK 130

  Fly   174 HGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVN 238
            |  .|.|::| :|....:..||||:|.:.......:.:.:.::.:|.:..||      :...|..
Human   131 H--ILLFNIS-IPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGT------DAWDSAT 186

  Fly   239 TTGDYV--------GWLELNVTEGLHEWL----VKSKDNHGIYIGAHAVNRPDREVKLDDIGLIH 291
            .|..::        ||..|.|:..:..|:    .|||:.              .||.::.    |
Human   187 ETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNK--------------LEVTVES----H 233

  Fly   292 RKVDDEFQ----------PFMIGFFRGP---------ELIKATAH-------------------S 318
            ||..|...          ||.:.|....         ||.:..:|                   |
Human   234 RKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGES 298

  Fly   319 SHHRSK----RSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYG 379
            ||....    .:.|...:||:|....:           .||..:|.::|:|:||..|||||:.|.
Human   299 SHEEDTDGHVAAGSTLARRKRSAGAGS-----------HCQKTSLRVNFEDIGWDSWIIAPKEYE 352

  Fly   380 AFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKK- 443
            |:.|.|.|.|||...:..|.||||||||||..|.||.|.||.||:|..:.|||. :|..|...|
Human   353 AYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK-DDMGVPTLKY 416

  Fly   444 -YRNMIVKSCGC 454
             |..|.|..|||
Human   417 HYEGMSVAECGC 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	51/282 (18%)
		TGFB	354..455	CDD:214556	52/103 (50%)
GDF2	NP_057288.1	TGFb_propeptide	76..257	CDD:279078	45/252 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..308		3/24 (13%)
		TGF_beta	326..428	CDD:278448	50/102 (49%)
		Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608	402..416		5/14 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810