DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gbb and GDF1

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001374367.1	Gene:	GDF1 / 2657	HGNCID:	4214	Length:	372	Species:	Homo sapiens

Alignment Length:	125	Identity:	46/125 - (36%)
Similarity:	69/125 - (55%)	Gaps:	13/125 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 PLLEPMESTR---------SCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPL----NAH 394
            ||..|.....         :|:.:.||:.|:::|||.|:|||.|:.|.||.|:|..|:    :..
Human   247 PLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGG 311

  Fly   395 MNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ..|.|||:::.|:|...|.....|||.|.||..:.||:..|.:||.|::|.:|:|..|||
Human   312 PPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	43/105 (41%)
GDF1	NP_001374367.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86
GDF1	NP_001374367.1	TGF_beta_GDF1_3_like	267..372	CDD:381642	43/105 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810