DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and Bmp6

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_038951315.1	Gene:	Bmp6 / 25644	RGDID:	2214	Length:	535	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	162/517 - (31%)
Similarity:	236/517 - (45%)	Gaps:	118/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHL---------- 81
            |....|..:::.||          .::|.|...:|.::..|||..||:..||..|
  Rat    49 VRAEQPPPQSSSSG----------FLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQSPV 103

  Fly    82 -----SSHQLSLR-------KSAPKFLLDVYHRITAEEGLSDQDEDDDYERG------------- 121
                 .|.|.:..       ||||.|:||:|:      .||..||:|....|
  Rat   104 LPQQQQSQQTAREEPPPGRLKSAPLFMLDLYN------SLSKDDEEDGVSEGEGLEPESHGRASS 162

  Fly   122 -----------HRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHNVD-ELRHEH 174
                       |...|.:.|....|.......:..|...::::|::|:|:|...::.: ..|..|
  Rat   163 SQLKQPSPGAAHSLNRKSLLAPGPGGSASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRH 227

  Fly   175 GRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNT 239
            .:...|::|.:|....:..||.|:|::...|.:  .|:.|.|::|.:...  .||....|..::|
  Rat   228 HKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSF--KNQTFLISIYQVLQE--HQHRDSDLFLLDT 288

  Fly   240 T---GDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPF 301
            .   ....||||.::|...:.|:|..:.|.|:.:.  .|.|....:.....||:.|....:.|||
  Rat   289 RVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLS--VVTRDGLHINPRAAGLVGRDGPYDKQPF 351

  Fly   302 MIGFFRGPELIKATAHSSHHRSKRSASHPRK---RKKSVSPNNVPL------LEPMESTRSCQMQ 357
            |:.||:..|:        |.|:.||||..|:   |.:|....:|..      ....|...:|:..
  Rat   352 MVAFFKVSEV--------HVRTTRSASSRRRQQSRNRSTQSQDVSRGSSASDYNSSELKTACKKH 408

  Fly   358 TLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTL---------------- 406
            .||:.|:||||.||||||:||.|.||.|||:||||||||||||||||||
  Rat   409 ELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVSALTWLVGPGLDPVS 473

  Fly   407 -------------VHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH 455
                         |||:.|:.|||||||||:|.|:.|||..::.||.|||||||:|::||||
  Rat   474 FLTVSSHASLLEQVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	72/310 (23%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	70/129 (54%)
Bmp6	XP_038951315.1	TGFb_propeptide	58..355	CDD:395559	74/318 (23%)
Bmp6	XP_038951315.1	TGF_beta_BMP6	404..535	CDD:381666	70/130 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3618
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3028
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	1	1.000	-	-		otm46154
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930