DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gbb and Inhbb

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_032407.1	Gene:	Inhbb / 16324	MGIID:	96571	Length:	411	Species:	Mus musculus

Alignment Length:	301	Identity:	82/301 - (27%)
Similarity:	128/301 - (42%)	Gaps:	75/301 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 RLWFDVSNVPNDN-YLVMAELRIYQN-----ANEGKWLTANREFTITVYAIGTGTLGQ-HTMEPL 234
            ||:|.|||..|.| ::|.|.|.:|..     ..:|    :.|:..:.||....|...: :.:|..
Mouse   162 RLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKG----SRRKVRVKVYFQEQGHGDRWNVVEKK 222

  Fly   235 SSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLD-------DIGLIHR 292
            ..:..:    ||....:||.:..                ...|.:|.:.||       ::.::..
Mouse   223 VDLKRS----GWHTFPITEAIQA----------------LFERGERRLNLDVQCDSCQELAVVPV 267

  Fly   293 KVD---DEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSC 354
            .||   :..:||::        ::|....|.||.       |||.          ||....|..|
Mouse   268 FVDPGEESHRPFVV--------VQARLGDSRHRI-------RKRG----------LECDGRTSLC 307

  Fly   355 QMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGEC-----NFPLNAHMNATNHAIV-QTLVHLLEPK 413
            ..|..:|||:.:||:||||||.||...||.|.|     ..|.:|  ::.:.|:| |..:..|.|.
Mouse   308 CRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSA--SSFHTAVVNQYRMRGLNPG 370

  Fly   414 KVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            .| ..||.||:|.::.:||..::.|:..:...||||:.|||
Mouse   371 PV-NSCCIPTKLSSMSMLYFDDEYNIVKRDVPNMIVEECGC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	30/144 (21%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	42/107 (39%)
Inhbb	NP_032407.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..69
		TGFb_propeptide	73..282	CDD:307025	30/151 (20%)
		TGFB	307..410	CDD:214556	40/105 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810