Protein Alignment gbb and Gdf2

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_062379.3
• Gene: Gdf2 / 12165
• MGIID: 1321394
• Length: 428
• Species: Mus musculus
• Alignment Length: 513
• Identity: 121/513 - (23%)
• Similarity: 187/513 - (36%)
• Gaps: 173/513 - (33%)

  Fly    19 LGMVLLMFVATTPPAV--------EATQSGIYIDNGKDQTIMH-RVLSEDDKLDVSYEILEFLGI 74
            |.:.||:.|....|..        |...|.:.:....::.:.. ::..|:.|:|    .|..|.:
Mouse    11 LPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLSGAGEEGVFDLQMFLENMKVD----FLRSLNL 71

  Fly    75 AERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQK 139
            :..|:     |...|...|::::|:|:|.|.
Mouse    72 SGIPS-----QDKTRAEPPQYMIDLYNRYTT---------------------------------- 97

  Fly   140 NFITDLDKRAIDESDIIMTFLNKRHHNVDEL------------RHEHGRRLWFDVSNVPNDNYLV 192
                  ||.:...|:|:.:|      :|::.            :|    .|.|::| :|....:.
Mouse    98 ------DKSSTPASNIVRSF------SVEDAISTAATEDFPFQKH----ILIFNIS-IPRHEQIT 145

  Fly   193 MAELRIYQNANEGKWLTANREFTITVY-----------AIGTGTLGQHTMEPLSSVNTTGDYVGW 246
            .||||:|.:.......|...|.::.||           |.||.|.       |.|.:...:  ||
Mouse   146 RAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQATGTKTF-------LVSQDIRDE--GW 201

  Fly   247 LELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQ----------PF 301
            ..|.|:..:..|:....          ..|:...||.:..    ||:..|...          ||
Mouse   202 ETLEVSSAVKRWVRADS----------TTNKNKLEVTVQS----HRESCDTLDISVPPGSKNLPF 252

  Fly   302 ---------------------MIGFFRGPELIKATAHSSHHRSKRSASHP------------RKR 333
                                 |||..:...|:| ||.:::..:..|....            .:|
Mouse   253 FVVFSNDRSNGTKETRLELKEMIGHEQETMLVK-TAKNAYQVAGESQEEEGLDGYTAVGPLLARR 316

  Fly   334 KKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNAT 398
            |:|..           ::..||..:|.::|:|:||..|||||:.|.|:.|.|.|.|||...:..|
Mouse   317 KRSTG-----------ASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPT 370

  Fly   399 NHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKK--YRNMIVKSCGC 454
            .||||||||||..|.||.|.||.||:|..:.:||. :|..|...|  |..|.|..|||
Mouse   371 KHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYK-DDMGVPTLKYHYEGMSVAECGC 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	54/314 (17%)
		TGF_beta_BMP5_like	353..455	CDD:381639	51/104 (49%)
Gdf2	NP_062379.3	TGFb_propeptide	69..215	CDD:480997	40/210 (19%)
		TGF_beta_BMP9	324..428	CDD:381670	51/105 (49%)
		Interaction with ENG. /evidence=ECO:0000250|UniProtKB:Q9UK05	401..415		4/14 (29%)