Protein Alignment gbb and LEFTY1

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_066277.1
• Gene: LEFTY1 / 10637
• HGNCID: 6552
• Length: 366
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 81/393 - (20%)
• Similarity: 134/393 - (34%)
• Gaps: 136/393 - (34%)

  Fly   135 GEQ---------QKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRR------------- 177
            |||         |...:..||:..::|. :|.|.:..::  |..|:..||.|
Human    24 GEQLLGSLLRQLQLKEVPTLDRADMEEL-VIPTHVRAQY--VALLQRSHGDRSRGKRFSQSFREV 85

  Fly   178 -------------LWFDV-SNVPNDNYLVMAELRIYQNA-------NEGKWLTANREFTITVYAI 221
                         |.|.: ..:|.::.||.|.||::|..       ..|:....:....:||..:
Human    86 AGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWL 150

  Fly   222 GTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDD 286
            .....|.:....:.|...:....||...:|||.::.|              ..::||
Human   151 RVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFW--------------QQLSRP-------- 193

  Fly   287 IGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSV-SPNNV--PLLE-- 346
                                |.|.|::.:....|.....|.:|...|..|. :|..:  |.||
Human   194 --------------------RQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELH 238

  Fly   347 -----------------PM-ESTRSCQMQTLYIDFKDLGW-HDWIIAPEGYGAFYCSGECNFPLN 392
                             || |.||.|: |.:|||.:.:.| .:|::.|.|:.|:.|.|.|..|..
Human   239 TLDLGDYGAQGDCDPEAPMTEGTRCCR-QEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQPPE 302

  Fly   393 AHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLND------ENVNLKKYRNMIVKS 451
            |             :....|...|:.|.| :...:||::..:.:      :.|:|.   ||.|:.
Human   303 A-------------LAFKWPFLGPRQCIA-SETDSLPMIVSIKEGGRTRPQVVSLP---NMRVQK 350

  Fly   452 CGC 454
            |.|
Human   351 CSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	36/212 (17%)
		TGFB	354..455	CDD:214556	28/108 (26%)
LEFTY1	NP_066277.1	TGFb_propeptide	<106..214	CDD:307025	24/149 (16%)
		TGF_beta	263..353	CDD:306518	27/107 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810