Protein Alignment gbb and GDF11

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 108/488 - (22%)
• Similarity: 172/488 - (35%)
• Gaps: 126/488 - (25%)

  Fly    11 VAVLASLGLGMVLLMF------------VATTPPAVEATQSGIYIDNGKDQT------------- 50
            :.:.|.|.||.:||..            .|....|..|..:|:    |.:::
Human     1 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGV----GGERSSRPAPSVAPEPDG 61

  Fly    51 ---IMHRVLSEDDKLD-VSYEILEFLGIAERPTHLSSHQLSLRKSAPKF--LLDVYHRITAEEGL 109
               .:.|..|.:.:|: :..:||..|.:.|.|.........|...||..  :||::.  ...:.|
Human    62 CPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHD--FQGDAL 124

  Fly   110 SDQD--EDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHN-----V 167
            ..:|  |:|:|.....:..|...|.|...|            .|.|.:...|    |.:     .
Human   125 QPEDFLEEDEYHATTETVISMAQETDPAVQ------------TDGSPLCCHF----HFSPKVMFT 173

  Fly   168 DELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTA------NREFTITVYAIGTGTL 226
            ..|:    .:||..:..||....:.:..||:.....||   ||      .|...|....|...:.
Human   174 KVLK----AQLWVYLRPVPRPATVYLQILRLKPLTGEG---TAGGGGGGRRHIRIRSLKIELHSR 231

  Fly   227 GQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIH 291
            ..|                |..::..:.||.|..:.:.|.||.|.|...:..|..|.....|.
Human   232 SGH----------------WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA-- 278

  Fly   292 RKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQM 356
                :...|||       ||             |...:.::.::::   .:...|....:|.|:
Human   279 ----EGLHPFM-------EL-------------RVLENTKRSRRNL---GLDCDEHSSESRCCR- 315

  Fly   357 QTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCA 421
            ..|.:||:..|| ||||||:.|.|.||||:|.:........|:      ||....|:....|||.
Human   316 YPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCT 373

  Fly   422 PTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ||::..:.:||..:.:.:...|...|:|..|||
Human   374 PTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	57/292 (20%)
		TGFB	354..455	CDD:214556	36/101 (36%)
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:366248	54/270 (20%)
		TGF_beta_GDF8	301..407	CDD:381658	38/114 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810