Protein Alignment gbb and nodal5

DIOPT Version :10

• Sequence 1: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_002945280.2
• Gene: nodal5 / 100495007
• XenbaseID: XB-GENE-483267
• Length: 386
• Species: Xenopus tropicalis
• Alignment Length: 418
• Identity: 106/418 - (25%)
• Similarity: 176/418 - (42%)
• Gaps: 82/418 - (19%)

  Fly    81 LSSHQLSLRKSAPKFLLDVYHRITAE---EGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFI 142
            ||...|||....|..|    |...|.   :|.:.:.|......|.|............:..:|.|
 Frog     8 LSLTILSLGHGMPTLL----HTKEARFPLQGSTQRLESSSVLHGKRLPHDMKYPVYMVQMYQNLI 68

  Fly   143 TDLDKR-------AIDESDIIMTFLNKRHHNVDELRHEHGRRLW---FDVSNVPNDNYLVMAELR 197
            :..||.       .:.|||.:::.:.|....||.        .|   ||:|::...:.|.:||||
 Frog    69 SGTDKSPSVRGEPVLQESDTVLSLIAKGCTQVDS--------QWILSFDMSSISISSELRLAELR 125

  Fly   198 IYQNANEGKWLTANREFTITVYAIGTGTLGQHT---MEPLSSVNTTGDYVG-----WLELNVTEG 254
            |:..:     |...:..|:.:|         ||   :|.....:.|.|:.|     |...|||:.
 Frog   126 IHLPS-----LERFQNVTLDIY---------HTKGNLEKFFLGSLTIDFPGTSGSSWKVFNVTQM 176

  Fly   255 LHEWLVK----SKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFF--------- 306
            |..:|.:    |.|.   |....|.::.::::..:  ||:..::       |:..|
 Frog   177 LQRYLYQKESFSSDK---YTQPKATSQAEQKISCN--GLLSERI-------MLMVFSTDKPSSKL 229

  Fly   307 RGPELIKATAHSSHH----RSKRSASHPRKRKKSVSPNNVPL----LEPMESTRS-CQMQTLYID 362
            .|...:..||.||.:    ...|.....|.|:...:.|::..    .:|:...:: |:...:.:|
 Frog   230 TGSTSLIETAESSKYVITEADTRETGKRRHRRNRYALNSIIRSSFHSQPVGDGKTLCRRVDMIVD 294

  Fly   363 FKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGA 427
            |:.:||.|.||.|:.:.|:.|.|.|..|||.:...||||.:::||:...|.:|..|.|.|.::..
 Frog   295 FEKIGWSDRIIYPKRFNAYRCEGSCPIPLNENFKPTNHAYIKSLVNHFNPGRVECPSCIPVKMRP 359

  Fly   428 LPVLYHLNDENVNLKKYRNMIVKSCGCH 455
            |.:|.:..||.| ||.:.:|||:.|||:
 Frog   360 LSMLMYEGDEIV-LKHHEDMIVEECGCY 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	55/248 (22%)
		TGF_beta_BMP5_like	353..455	CDD:381639	39/102 (38%)
nodal5	XP_002945280.2	TGFb_propeptide	57..186	CDD:480997	35/150 (23%)
		TGF_beta_NODAL	284..385	CDD:381637	38/101 (38%)