DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and gdf2

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_002940692.2	Gene:	gdf2 / 100485289	XenbaseID:	XB-GENE-478184	Length:	410	Species:	Xenopus tropicalis

Alignment Length:	481	Identity:	114/481 - (23%)
Similarity:	207/481 - (43%)	Gaps:	114/481 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLASLGLGMVLLMFVATTPPAVEATQSGIYIDN------GKDQTIMHRVLSEDDKLDVSYEILEF 71
            :..|:.|.::::.|...|..:::    |:...|      .|.:.||...:....|     |.|..
Frog     4 ITLSVVLSIIIIFFDTVTNKSLQ----GLAPRNHHRHYEEKPEDIMSLFMENTKK-----EFLWG 59

  Fly    72 LGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGE 136
            |.::..|:     |..::|..|:|::::|:|.:.::.|                          :
Frog    60 LNLSGVPS-----QDKIKKMPPQFMIELYNRFSEDKTL--------------------------K 93

  Fly   137 QQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQN 201
            ...|.|     |:.:..||:.:      ..:::....|  .:.|:|| :|....|..|||::|
Frog    94 PVSNII-----RSFNAEDILSS------SALEDTFQSH--IVLFNVS-IPQHEELTEAELKMY-- 142

  Fly   202 ANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYV--------GWLELNVTEGLHEW 258
            .:.||....:    :.||.|      .:| ||..::......:        |||.:|||..:..|
Frog   143 VSLGKKYHGH----LLVYDI------LYT-EPFENLRYPKSLIESKIIERSGWLSINVTRAVKRW 196

  Fly   259 LVKSK--DNHGIYIGAHAVNRP-DREVKLDDIGLIHR---KVDDEFQPFMIGF----FRGPELIK 313
            :..|:  ....|::|:   |:| :..::|.|    :|   |::..:.|.::.|    :..|:..|
Frog   197 ITSSRITKKLEIFLGS---NKPLNSCLRLQD----NRRGVKINSSYPPVLLVFSDDKWSKPQKTK 254

  Fly   314 -------------ATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKD 365
                         .|...|...:.:.|::..|.......|....::..::|..|:..:|.::|||
Frog   255 MERKEIIFHEENIGTQTVSKKNTVKYANNGHKNWNFGLGNGKMRVKRSQATNYCRKSSLKVNFKD 319

  Fly   366 LGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPV 430
            :||..|||:|..|.|:.|.|||.:||..::..|.|||:|||:|...||...|.||.||:|..:.:
Frog   320 IGWDSWIISPPEYDAYECKGECYYPLTDNLTPTKHAIIQTLMHFKNPKITRKACCVPTQLEPISI 384

  Fly   431 LYHLNDENVNLKKYR--NMIVKSCGC 454
            .| ::|:.:...||:  .|.|..|||
Frog   385 FY-IDDKGIPTMKYKYEGMKVAKCGC 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	56/280 (20%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	44/103 (43%)
gdf2	XP_002940692.2	TGFb_propeptide	60..208	CDD:366248	40/205 (20%)
gdf2	XP_002940692.2	TGF_beta_BMP9	306..410	CDD:381670	44/105 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910