Protein Alignment gbb and gdf5

DIOPT Version :9

• Sequence 1: NP_001286786.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_002662587.1
• Gene: gdf5 / 100334210
• ZFINID: ZDB-GENE-990415-39
• Length: 474
• Species: Danio rerio
• Alignment Length: 493
• Identity: 124/493 - (25%)
• Similarity: 190/493 - (38%)
• Gaps: 150/493 - (30%)

  Fly     2 SGLRNTSEAVAVLASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSY 66
            |.:::.|:|.:...|            :.|.||.|..:||
Zfish    91 SSIQHHSKAASTQKS------------SAPAAVRAAPAGI------------------------- 118

  Fly    67 EILEFLGIAERPTHLSSHQLSLRKSAPK----------------FLLDVYHRITAEEGLSDQDED 115
                 ..||..|:||.      .|||.|                ::|.:|..:|:    .|.:..
Zfish   119 -----KSIAPAPSHLR------MKSAVKLENSEEPKHPLVIPHDYMLSLYWSLTS----GDVNTS 168

  Fly   116 DDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWF 180
            ..:|.|                ..|.||....|..||             ....||.:   |..|
Zfish   169 VLHEAG----------------MANTITSFVDRGQDE-------------RAPLLRRQ---RYVF 201

  Fly   181 DVSNVPNDNYLVMAELRIY-------QNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVN 238
            ::|::..:. |:.|||||.       :.|...:.:...|.||.   |.|..........|..|
Zfish   202 NISSMEKEG-LLGAELRILRKKHMDSRKATFSEGMAVLRLFTC---ASGKNAAVLLQARPFDS-- 260

  Fly   239 TTGDYVGWLELNVTEGLHEWLV--KSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPF 301
            .:..|  |...::      |.|  ..::...:.:...||:. .|.:.|..:||.......:.:.|
Zfish   261 HSASY--WEVFDI------WKVFKNFRNTPQLCLELDAVDH-GRPLDLRLLGLSRAGRQTKEKAF 316

  Fly   302 MIGF----FRGPELIKATAHSSH-----------HRSKRSASHPRKRKKSVSPNNVPLLEPMEST 351
            .:.|    .||....:..|.|.|           .|..|.|..||.:|        |:..|.:
Zfish   317 FVVFGRTKKRGLFYNEIKARSGHDNKTVYEYLFTQRRMRRAPLPRGKK--------PIKNPKQ-- 371

  Fly   352 RSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVP 416
             .|..:.|:::||::||.||||||..|.||:|.|.|:||:.:|:..|||||:|||::.::|:..|
Zfish   372 -RCNRKQLHVNFKEMGWDDWIIAPLEYEAFHCDGVCDFPIRSHLEPTNHAIIQTLMNSMDPRSTP 435

  Fly   417 KPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            ..||.||||..:.:||..:..||..|:|.:|:|:||||
Zfish   436 PTCCVPTRLSPISILYIDSANNVVYKQYEDMVVESCGC 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	51/285 (18%)
		TGFB	354..455	CDD:214556	49/101 (49%)
gdf5	XP_002662587.1	TGFb_propeptide	138..320	CDD:279078	42/232 (18%)
		TGF_beta	371..473	CDD:278448	47/104 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810