DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and gdf5

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001128589.1	Gene:	gdf5 / 100189547	XenbaseID:	XB-GENE-481784	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	128/498 - (25%)
Similarity:	210/498 - (42%)	Gaps:	129/498 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PAVEATQSGIY-----IDNGKDQT--IMHRVL---SEDDKLDVSYEILEFL--GIAE-------- 76
            |.|.||::||.     :..|:.:.  :..|:.   :||.|...:......:  |.||
Frog    52 PKVNATRTGILGHGVGLQKGRSKVPLVQSRIFLSKNEDIKKQAASRANPHVKTGNAENRQSGEKI 116

  Fly    77 ---RPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQ 138
               ||.|::|      |::.|.:     .|.|:..            |.:.:|..: ...|.||:
Frog   117 ETPRPPHVTS------KASTKLI-----NIHADSA------------GFKPKRPPN-PLTEKEQK 157

  Fly   139 KNF-----------------ITDLDKRAIDES--------DIIMTFLNKRHHNVDELRHEHGRRL 178
            ..|                 ::|::::.|:.|        :.|.:|::|...  :.:.....::.
Frog   158 DAFKHPLITPHEYMLSLYRTLSDVERKGINGSLKLEAGLANTITSFIDKGQD--ERMAAARRQKY 220

  Fly   179 WFDVSNVPNDNYLVMAELRIYQNAN-EGKWLTANREFTITVYAIGTGTLGQHTME--PLSSVNTT 240
            .||:|.:..|. |:.|||||.:... :.|..:|.:.:.|.:|:..........::  ||.|::|.
Frog   221 TFDISALEKDG-LLGAELRILRKRPIDAKLNSAGKLWQIKLYSCPANKKSATLLDSRPLGSIDTP 284

  Fly   241 GDYVGW-------LELNVTEGLH-----EWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIH-- 291
                .|       |..|....:.     |.|.|.|......:|   .||..|:.....|.|:.
Frog   285 ----KWEVFDIWKLYKNFKNSVQLCFELEVLDKGKPADLRSVG---FNRTGRQTNEKAIFLVFGR 342

  Fly   292 -RKVDDEFQPFMIGFFRGPELIKATA---------HSSHHRSKRSASHPRKRKKSVSPNNVPLLE 346
             :|.|..|..           |||.:         :..:.|.||.|  |...::...||.
Frog   343 TKKRDLFFNE-----------IKARSGQDDKTVYEYLFNQRRKRRA--PLSTRQGKRPNK----- 389

  Fly   347 PMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLE 411
              .|...|..:.|:::|||:||.||||||..|.|::|.|.|.|||.:|:..||||::|||::.::
Frog   390 --NSKARCSKKPLHVNFKDMGWDDWIIAPLEYEAYHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD 452

  Fly   412 PKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454
            |:..|..||.||||..:.:||..:..||..|:|.:|:|:||||
Frog   453 PETTPPTCCVPTRLSPISILYTDSANNVVYKQYEDMVVESCGC 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	62/321 (19%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	49/101 (49%)
gdf5	NP_001128589.1	TGFb_propeptide	142..328	CDD:279078	39/196 (20%)
gdf5	NP_001128589.1	TGFB	395..496	CDD:214556	49/101 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910