DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbb and bmp6

DIOPT Version :9

Sequence 1:	NP_001286786.1	Gene:	gbb / 37778	FlyBaseID:	FBgn0024234	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001106378.1	Gene:	bmp6 / 100127176	XenbaseID:	XB-GENE-479134	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	162/457 - (35%)
Similarity:	234/457 - (51%)	Gaps:	80/457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GIYID--NGKDQTIMHRVLSEDDKLDVSYEILEFLGIAE--RPTH-LSSHQLS---LRKSAPKFL 96
            |..:|  :..|...::|.|...:|.::..|||..||:..  ||.| ||..||:   ...|||.|:
Frog    24 GTLVDKRSSMDSGFLYRRLKSHEKREMQKEILSILGLPHRPRPIHGLSPSQLNQPGKLNSAPLFM 88

  Fly    97 LDVYHRITAEEGLSDQDEDDDYE--------RGHRSRRSADLEEDEGEQQKNFITDLDKRAIDES 153
            ||:|:      .:|.||:..|.:        ..|:.:..:.|....|..|       |...:.::
Frog    89 LDLYN------AMSGQDQGMDLKDWSHRATLHSHQLKVKSLLGSHLGSAQ-------DSAFLSDA 140

  Fly   154 DIIMTFLNKRHHNVDELRHEHGRRLW------FDVSNVPNDNYLVMAELRIYQNANEGKWLTANR 212
            |::|:|:|...|:.|     ...|||      |::|.:|....:..||.|||::...|.:  .|:
Frog   141 DMVMSFVNLVEHDKD-----LSPRLWHHKEYKFNLSQIPEGEAVTAAEFRIYKDCVLGSF--ENQ 198

  Fly   213 EFTITVYAIGTGTLGQHTMEP-----LSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGA 272
            .|.|::|.:    |.:|....     |.:........||||.::|...:.|::..:.|.|:.:
Frog   199 TFLISIYQV----LAEHRNRETNIFLLDTQTVWASDEGWLEFDITATSNLWVMNPRHNFGLQL-- 257

  Fly   273 HAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRK----- 332
            ....|..|.:.....||:.|....:.||||:.||:..|:        |.|:.|||:..||
Frog   258 RVETRDGRNINAKAAGLVGRDGPYDKQPFMVAFFKASEV--------HLRTTRSATSKRKNQNRN 314

  Fly   333 ---------RKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECN 388
                     |..|::..|     ..|...:|:...||:.|:||||.||||||:||.|.||.|||:
Frog   315 RYTQAQDVSRVSSITDYN-----SSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCGGECS 374

  Fly   389 FPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCG 453
            |||||||||||||||||||||:.|:.|||||||||:|.|:.|||..::.||.|||||||:|::||
Frog   375 FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACG 439

  Fly   454 CH 455
            ||
Frog   440 CH 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbb	NP_001286786.1	TGFb_propeptide	44..305	CDD:279078	75/287 (26%)
gbb	NP_001286786.1	TGFB	354..455	CDD:214556	70/100 (70%)
bmp6	NP_001106378.1	TGFb_propeptide	32..290	CDD:366248	74/283 (26%)
bmp6	NP_001106378.1	TGF_beta_BMP6	339..441	CDD:381666	70/101 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3042
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	1	1.000	-	-		otm49237
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4460
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100