DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF6 and eif6

DIOPT Version :9

Sequence 1:	NP_659573.1	Gene:	eIF6 / 37776	FlyBaseID:	FBgn0034915	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_957238.1	Gene:	eif6 / 386850	ZFINID:	ZDB-GENE-031118-110	Length:	245	Species:	Danio rerio

Alignment Length:	245	Identity:	181/245 - (73%)
Similarity:	218/245 - (88%)	Gaps:	0/245 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALRVQFENNDDIGVFTKLTNTYCLVAIGGSETFYSAFEAELGDTIPVVHANVGGCRIIGRLTVG 65
            ||:|..||.|::||.|.|||||||||||||||.||||||.||.:|:||:||::.|||||||:.||
Zfish     1 MAVRASFEKNNEIGCFAKLTNTYCLVAIGGSENFYSAFEGELSETMPVIHASIAGCRIIGRMCVG 65

  Fly    66 NRNGLLVPNSTTDEELQHLRNSLPDAVKIYRVEERLSALGNVIACNDYVALVHPDLDKETEEIIA 130
            ||:||||||:|||:||||:||.|||:|:|.|||||||||||||||||||||||||||:|||||:|
Zfish    66 NRHGLLVPNNTTDQELQHIRNCLPDSVRIQRVEERLSALGNVIACNDYVALVHPDLDRETEEILA 130

  Fly   131 DVLKVEVFRQTIADNSLVGSYAVLSNQGGMVHPKTSIQDQDELSSLLQVPLVAGTVNRGSEVLAA 195
            |.|||||||||:|:..|||||...|||||:||.||||:||||||||||||||||||||||||:||
Zfish   131 DTLKVEVFRQTVAEQVLVGSYCAFSNQGGLVHAKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAA 195

  Fly   196 GMVVNDWLSFVGMNTTATEISVIESVFKLNQAQPATVTTKLRAALIEDMS 245
            |||||||.:|.|::||:||:|||||||:|::.||:.:.|.:|.:||:.::
Zfish   196 GMVVNDWCAFCGLDTTSTELSVIESVFRLSETQPSAIATTMRDSLIDSLT 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF6	NP_659573.1	PTZ00136	1..245	CDD:185471	181/243 (74%)
eif6	NP_957238.1	PTZ00136	1..244	CDD:185471	181/242 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578455
Domainoid	1	1.000	330	1.000	Domainoid score	I1133
eggNOG	1	0.900	-	-		E1_COG1976
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7135
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2030
OMA	1	1.010	-	-		QHG62170
OrthoDB	1	1.010	-	-		D1157302at2759
OrthoFinder	1	1.000	-	-		FOG0003965
OrthoInspector	1	1.000	-	-		oto40354
orthoMCL	1	0.900	-	-		OOG6_101255
Panther	1	1.100	-	-	LDO	PTHR10784
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R598
SonicParanoid	1	1.000	-	-		X2729
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800