DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF6 and EIF6

DIOPT Version :9

Sequence 1:	NP_659573.1	Gene:	eIF6 / 37776	FlyBaseID:	FBgn0034915	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_001254739.1	Gene:	EIF6 / 3692	HGNCID:	6159	Length:	245	Species:	Homo sapiens

Alignment Length:	245	Identity:	190/245 - (77%)
Similarity:	220/245 - (89%)	Gaps:	0/245 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALRVQFENNDDIGVFTKLTNTYCLVAIGGSETFYSAFEAELGDTIPVVHANVGGCRIIGRLTVG 65
            ||:|..||||.:||.|.|||||||||||||||.|||.||.||.||||||||::.|||||||:.||
Human     1 MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVG 65

  Fly    66 NRNGLLVPNSTTDEELQHLRNSLPDAVKIYRVEERLSALGNVIACNDYVALVHPDLDKETEEIIA 130
            ||:||||||:|||:||||:||||||.|:|.||||||||||||..|||||||||||||:|||||:|
Human    66 NRHGLLVPNNTTDQELQHIRNSLPDTVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILA 130

  Fly   131 DVLKVEVFRQTIADNSLVGSYAVLSNQGGMVHPKTSIQDQDELSSLLQVPLVAGTVNRGSEVLAA 195
            |||||||||||:||..|||||.|.|||||:|||||||:||||||||||||||||||||||||:||
Human   131 DVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAA 195

  Fly   196 GMVVNDWLSFVGMNTTATEISVIESVFKLNQAQPATVTTKLRAALIEDMS 245
            |||||||.:|.|::||:||:||:|||||||:|||:|:.|.:|.:||:.::
Human   196 GMVVNDWCAFCGLDTTSTELSVVESVFKLNEAQPSTIATSMRDSLIDSLT 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF6	NP_659573.1	PTZ00136	1..245	CDD:185471	190/243 (78%)
EIF6	NP_001254739.1	PTZ00136	1..244	CDD:185471	190/242 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145141
Domainoid	1	1.000	339	1.000	Domainoid score	I1098
eggNOG	1	0.900	-	-		E1_COG1976
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7135
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1981
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62170
OrthoDB	1	1.010	-	-		D1157302at2759
OrthoFinder	1	1.000	-	-		FOG0003965
OrthoInspector	1	1.000	-	-		oto91368
orthoMCL	1	0.900	-	-		OOG6_101255
Panther	1	1.100	-	-	LDO	PTHR10784
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R598
SonicParanoid	1	1.000	-	-		X2729
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800