DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF6 and eif-6

DIOPT Version :9

Sequence 1:	NP_659573.1	Gene:	eIF6 / 37776	FlyBaseID:	FBgn0034915	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_493272.1	Gene:	eif-6 / 173169	WormBaseID:	WBGene00001234	Length:	246	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	151/245 - (61%)
Similarity:	200/245 - (81%)	Gaps:	1/245 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALRVQFENNDDIGVFTKLTNTYCLVAIGGSETFYSAFEAELGDTIPVVHANVGGCRIIGRLTVG 65
            |||||.:|.::|:|||..|||:||||.:||::.|||..||||.|.|||||.::...||:||||||
Worm     1 MALRVDYEGSNDVGVFCTLTNSYCLVGVGGTQNFYSILEAELSDLIPVVHTSIASTRIVGRLTVG 65

  Fly    66 NRNGLLVPNSTTDEELQHLRNSLPDAVKIYRVEERLSALGNVIACNDYVALVHPDLDKETEEIIA 130
            ||:||||||:|||:|||||||||||.|.|.||:||||||||||||||:||:||.::..|||:.:.
Worm    66 NRHGLLVPNATTDQELQHLRNSLPDEVAIRRVDERLSALGNVIACNDHVAIVHAEISAETEQALV 130

  Fly   131 DVLKVEVFRQTIADNSLVGSYAVLSNQGGMVHPKTSIQDQDELSSLLQVPLVAGTVNRGSEVLAA 195
            :||||||||.::|.|||||||.:||:.|.:|..:|..:.|.|:::|||:|:||||.|||||::.|
Worm   131 EVLKVEVFRVSLAQNSLVGSYCILSSNGCLVAARTPPETQREIAALLQIPVVAGTCNRGSELIGA 195

  Fly   196 GMVVNDWLSFVGMNTTATEISVIESVFKL-NQAQPATVTTKLRAALIEDM 244
            |||||||::|.|:::|:||:||:||:||| .|..|.:::.:||..|||.|
Worm   196 GMVVNDWVAFCGLDSTSTELSVVESIFKLGEQGAPTSISNQLRDTLIESM 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF6	NP_659573.1	PTZ00136	1..245	CDD:185471	151/245 (62%)
eif-6	NP_493272.1	IF6	1..246	CDD:294171	151/245 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158524
Domainoid	1	1.000	271	1.000	Domainoid score	I956
eggNOG	1	0.900	-	-		E1_COG1976
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7135
Inparanoid	1	1.050	316	1.000	Inparanoid score	I1525
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62170
OrthoDB	1	1.010	-	-		D1157302at2759
OrthoFinder	1	1.000	-	-		FOG0003965
OrthoInspector	1	1.000	-	-		oto17698
orthoMCL	1	0.900	-	-		OOG6_101255
Panther	1	1.100	-	-	LDO	PTHR10784
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R598
SonicParanoid	1	1.000	-	-		X2729
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840