Protein Alignment CG5554 and Pdia2

DIOPT Version :10

• Sequence 1: NP_001286784.1
• Gene: CG5554 / 37775
• FlyBaseID: FBgn0034914
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_001074539.1
• Gene: Pdia2 / 69191
• MGIID: 1916441
• Length: 527
• Species: Mus musculus
• Alignment Length: 312
• Identity: 71/312 - (22%)
• Similarity: 110/312 - (35%)
• Gaps: 109/312 - (34%)

  Fly    15 LLLLAATAQSTAAAQSGLQPGGK------------------LIELDEDNWHLMLQ--GEWMIEFF 59
            ||||...:.|..   .|.:|||.                  ::.|:.....|.||  ...|:||:
Mouse     9 LLLLLGVSGSWG---QGEEPGGPSEVLPEEPTGEEVPKEDGILVLNHRTLSLALQEHSALMVEFY 70

  Fly    60 APWCPACKNLAPTWERFARV--AKDVQVQVAKIDVTTSPSLSGRFFVTALPTIYHVKDGEF---R 119
            ||||..||.|||.:.:.|.:  |:...|.:||:|....|.|:..|.|...||:...::|..   .
Mouse    71 APWCGHCKELAPEYSKAAALLAAESAVVTLAKVDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPE 135

  Fly   120 QYRGARDGDALLYFVKK---------QQWQSIEPLSA-WKKPDTTHMSVLSYF------------ 162
            :|.|.:..:.:..::::         :..:.::.|.| |      .|.|:.:|
Mouse   136 EYAGPKTAEGIAEWLRRRVGPSATHLEDEEGVQALMAKW------DMVVIGFFQDLQGKDMATFL 194

  Fly   163 -------------------FKLSHTLKHTQKLFKDFN-GR----LQEEYGLPTWGSYALFAI--- 200
                               |:.....|.|..|||.|: ||    :.:|.||.. |..:.|.:
Mouse   195 ALAKDALDMTFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKETGLDL-GDLSRFLVIHS 258

  Fly   201 ------------ATIFVGAALGLLLV-----------CLVDF--VYPPKKSQ 227
                        ..||....|..||:           .|.||  ..||.:.|
Mouse   259 MHLVTEFNSQTSPKIFAAKILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQ 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5554	NP_001286784.1	PDI_a_TMX	36..136	CDD:239292	32/124 (26%)
Pdia2	NP_001074539.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..41		4/23 (17%)
		ER_PDI_fam	45..506	CDD:273457	62/273 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	524..527