Protein Alignment CG5554 and PDIA2

DIOPT Version :10

• Sequence 1: NP_001286784.1
• Gene: CG5554 / 37775
• FlyBaseID: FBgn0034914
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_006840.2
• Gene: PDIA2 / 64714
• HGNCID: 14180
• Length: 525
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 71/302 - (23%)
• Similarity: 115/302 - (38%)
• Gaps: 94/302 - (31%)

  Fly    15 LLLLAAT---AQSTAAAQSGLQPGGKLIELDEDNWHLMLQGE-----------WMIEFFAPWCPA 65
            ||||.|:   .|...|.....:|..:  |:.:::..|:|...           .::||:||||..
Human    11 LLLLRASCPWGQEQGARSPSEEPPEE--EIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGH 73

  Fly    66 CKNLAPTWERFARV--AKDVQVQVAKIDVTTSPSLSGRFFVTALPTIYHVKDGEF---RQYRGAR 125
            |:.|||.:.:.|.|  |:.:.|.:||:|......|:..|.||..||:...::|..   .:|.|.|
Human    74 CQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPR 138

  Fly   126 DGDALLYFVKKQQWQSIEPLSAWKKPDTT---------HMSVLSYF------------------- 162
            |.:.:..:::::    :.| ||.:..|..         .:.|:.:|
Human   139 DAEGIAEWLRRR----VGP-SAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDAL 198

  Fly   163 ------------FKLSHTLKHTQKLFKDFN-GR----LQEEYGLPTWGSYALFAI---------- 200
                        |:.....|.|..|||.|: ||    :.||.||.. |..:.|.:
Human   199 DMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDL-GDLSRFLVTHSMRLVTEF 262

  Fly   201 -----ATIFVGAALGLLLVCLVDFVYPPKKSQRQ---SFSES 234
                 |.||....|..||:    ||.....:.|:   .|.|:
Human   263 NSQTSAKIFAARILNHLLL----FVNQTLAAHRELLAGFGEA 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5554	NP_001286784.1	PDI_a_TMX	36..136	CDD:239292	31/115 (27%)
PDIA2	NP_006840.2	ER_PDI_fam	42..497	CDD:273457	62/269 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..525
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	522..525