Protein Alignment CG5554 and Txndc5

DIOPT Version :10

• Sequence 1: NP_001286784.1
• Gene: CG5554 / 37775
• FlyBaseID: FBgn0034914
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_663342.3
• Gene: Txndc5 / 105245
• MGIID: 2145316
• Length: 417
• Species: Mus musculus
• Alignment Length: 238
• Identity: 66/238 - (27%)
• Similarity: 103/238 - (43%)
• Gaps: 59/238 - (24%)

  Fly    38 LIELDEDNWHL-MLQGEWMIEFFAPWCPACKNLAPTWERFA-RVAKDVQVQVAKIDVTTSPSLSG 100
            |.||..:|:.| :.||...|:||||||..||.||||||:.| .:.....|::.|:|.|...::..
Mouse   177 LYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCS 241

  Fly   101 RFFVTALPTIYHVKDG-EFRQYRGARDGDALLYFVKKQQW------QSIEPLSA---WKKPDTTH 155
            ...|...||:...:|| :..||:|.||.::|..:|:.|..      :::||..|   ..:|....
Mouse   242 EHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDK 306

  Fly   156 MSVLSYFFKLSHTLKHTQKLFKDFNGRLQEEYGLPTWGSYALFAIATIFVGAALGLLLVCLVDFV 220
            .:||:.          |:|.|:|                       ||..|       :..|.|
Mouse   307 GTVLAL----------TEKSFED-----------------------TIAQG-------ITFVKF- 330

  Fly   221 YPPKKSQRQSFSESQDNLTE----GLEDLATEEIEDDGDAEEN 259
            |.|.....::.:.:.:.|::    ||.|:...|:  |..||.|
Mouse   331 YAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEV--DCTAERN 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5554	NP_001286784.1	PDI_a_TMX	36..136	CDD:239292	39/100 (39%)
Txndc5	NP_663342.3	PDI_a_ERp46	47..150	CDD:239303
		PDI_a_ERp46	176..276	CDD:239303	38/98 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..302		3/20 (15%)
		PDI_a_ERp46	308..409	CDD:239303	22/107 (21%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	414..417