Protein Alignment GlyT and SLC6A5

DIOPT Version :9

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 306/664 - (46%)
• Similarity: 420/664 - (63%)
• Gaps: 49/664 - (7%)

  Fly     8 GSAGVGGVGGGGGVV----CPSTAISGCASGTALIQLD---ATGPGAGGA--------GESEHER 57
            |..|...|..|.|.:    .|.......:..|.::..|   :..||:...        |:....|
Human   127 GPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKAR 191

  Fly    58 GTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAA 122
            |.|:.:.||:||::||:||||||||||||.:.|||||||||:.:||.:||||:.|:|:|.||:|:
Human   192 GNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFAS 256

  Fly   123 LGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYC 187
            .|||:|::.. |..:|.|..|:::|.::.:|||:||.:|:||:||||..||||.:|...|:|..|
Human   257 QGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPEC 320

  Fly   188 FSYAQ--ADQC--------EATNGTYYLR-----TCHNATSAAENNITTLALGALKRPPAEEYFN 237
            ....:  .|.|        :..|.|:.:.     |..|.||.|..   |...|      :||||.
Human   321 KDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANK---TFVSG------SEEYFK 376

  Fly   238 NFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGV 302
            .|||.:|.|||..|.|:..||.||||||.||:..|.||:::|||||||||.|||||||||.:|||
Human   377 YFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGV 441

  Fly   303 TLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVA 367
            |||||..||.:::||.|::|.:|.||.|||.||||:||.||||||||||||||.||||:|:|||.
Human   442 TLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVT 506

  Fly   368 FCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVML 432
            ..|.|||.|||.||||:|||:|:|..|::|.|.|||.|:||:||||.:||||:||.||::||:||
Human   507 CTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLML 571

  Fly   433 LTLGLDSQFALMETVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYA 496
            ||||||:.||.:||:.|:|.|.||. ||.:|....|...|..:|.|....|..|:|..||:|.||
Human   572 LTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYA 636

  Fly   497 ANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWV 561
            |::::::|||.|.:.|:::||.|||..||:.|||.:.   |.||.:.|.::||..|.|||.|::.
Human   637 ASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQP---NIFWKVCWAFVTPTILTFILCFSFY 698

  Fly   562 EYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPA 626
            :::|..||.|.||.|:..:||::....|:.|.::...::..||.  .|.:|:|.:..|..:|||.
Human   699 QWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG--RFIERLKLVCSPQPDWGPF 761

  Fly   627 GRPCVNLHAERYQS 640
               ......|||::
Human   762 ---LAQHRGERYKN 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	283/561 (50%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	295/600 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	571	1.000	Domainoid score	I225
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37901
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1183
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51490
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10344
SonicParanoid	1	1.000	-	-		X6052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760