DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and Slc6a11

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_077348.1	Gene:	Slc6a11 / 79213	RGDID:	628737	Length:	627	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	261/633 - (41%)
Similarity:	370/633 - (58%)	Gaps:	73/633 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GVGGVGGGGGVVCPSTAISGCASGTALIQLDATGPGAGGAGESE----HERGTWTGRFDFLLSLL 71
            |...:|||||                         ||.|..|:.    ||||.|..:.:|:||:.
  Rat    20 GSEALGGGGG-------------------------GAAGTREARDKAVHERGHWNNKVEFVLSVA 59

  Fly    72 GYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLF 136
            |..:|||||||||||||.|||||||||:.:..:..|:|:.|:|.:.||:.:.|.:..:||.||||
  Rat    60 GEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLF 124

  Fly   137 RGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNG 201
            .|:|....::.|.:.:||.:|:||.|||:...|...|||..|...|:|:.|..:      :..|.
  Rat   125 EGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEF------QKLNF 183

  Fly   202 TYYLR-TCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAW 265
            :.|.. :..||||                 |..|::...||.:|.|||..|:::..||.||..||
  Rat   184 SNYSHVSLQNATS-----------------PVMEFWERRVLAISDGIEHIGNLRWELALCLLAAW 231

  Fly   266 TIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGD 330
            ||.:.|:.||.:|:|||||.||.|||::|:||.:|||||||||.||.|||.||..:|::.|||.|
  Rat   232 TICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVD 296

  Fly   331 AAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVD 395
            |..||||:.:...|.|..|.|||.::||||:|.:::...|..|||.||..|||::||:|:|..|.
  Rat   297 AGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVP 361

  Fly   396 VEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL-- 458
            :.:|.:.|.|||||.||:.||.:|:||:||.|||:||:.|||||||..:|::.||::|.:|.:
  Rat   362 IAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFR 426

  Fly   459 RQY-KIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWIYGSQRF 521
            |.| :..::|:::|..|..||...|..|||..||.|.|||:...|| :||.||:.|.|:|||.||
  Rat   427 RGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRF 491

  Fly   522 LNDIQGMIGKR-----SWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH-YVYPMWADAV 580
            .::|:.|||.|     .|        .|:.:||.....|..|..|:|||.||.: |.||.|...:
  Rat   492 YDNIEDMIGYRPLSLIKW--------CWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGI 548

  Fly   581 GWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPAGR 628
            ||::.|..:|.|.|..|.::|:...:|.  ::::.|..|:|:....|:
  Rat   549 GWLMALSSMLCIPLWIFIKLWKTEGTLP--EKLQKLTVPSADLKMRGK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	244/556 (44%)
Slc6a11	NP_077348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		9/40 (23%)
Slc6a11	NP_077348.1	SLC6sbd_GAT3	44..585	CDD:212077	247/573 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820