Protein Alignment GlyT and SLC6A13

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 249/618 - (40%)
• Similarity: 362/618 - (58%)
• Gaps: 67/618 - (10%)

  Fly    40 LDATGPGAGGAGESEH--------------ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNN 90
            :|:...|....||::.              |||.|..:.:|:||:.|..:|||||||||||||.|
Human     1 MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKN 65

  Fly    91 GGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYN 155
            |||||.||:.:.|...|:|:..:|.:.|||.:.|.|..:|:.||:|.|:|....::..::.:||.
Human    66 GGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYI 130

  Fly   156 LIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNIT 220
            :::||.:||:|:||...|||..|...|:|::|..:      :.|||:.. .|..||||
Human   131 IVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEF------QKTNGSLN-GTSENATS------- 181

  Fly   221 TLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYF 285
                      |..|::...||.:|.||:..|:::..||.||.|||.|.:.|:.|||:|:||||||
Human   182 ----------PVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYF 236

  Fly   286 TALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLS 350
            ||.|||::||:|.:||||||||:.||.|||.|:..:|.:.|||.||..||||:.:...|.|..|.
Human   237 TATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALG 301

  Fly   351 SYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVV 415
            ||||:.||||:|.:.:.|.|..|||.||..||||:||::.|..|.:.:|.:.|.|||||.||..|
Human   302 SYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366

  Fly   416 TRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL---RQYKIWVVLSVAIFGYIGG 477
            ..||.||:||..||.|::.|||||||..:|::.||::|.:|::   :..:..::|.|::..::.|
Human   367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVG 431

  Fly   478 LGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWG 541
            |...|..|||..||.|.|||:...|| :||.|.:.:||:||::||.::|:.|||.|.|....:
Human   432 LIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKY-- 494

  Fly   542 IMWRYITPATLLFILFFNWVEYKPAKYG-HYVYPMWADAVGWIVGLLPVLVIFLVAFQEIW---- 601
             .|.::|||.......|:.::|.|..|. .|.||.|.||:||::.|..::.|      ..|
Human   495 -CWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCI------PAWSLYR 552

  Fly   602 ----RAPMSLSFRDRIKHLLQPTAEW---GPAG 627
                :.|    ||:||:.|:.|..:.   .|||
Human   553 LGTLKGP----FRERIRQLMCPAEDLPQRNPAG 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	233/544 (43%)
		Herpes_BLLF1	<884..1135	CDD:282904
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/20 (20%)
		SLC6sbd_GAT2	32..575	CDD:271396	241/579 (42%)