Protein Alignment GlyT and SLC6A11

DIOPT Version :9

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 253/616 - (41%)
• Similarity: 364/616 - (59%)
• Gaps: 60/616 - (9%)

  Fly    30 GCASGTALIQLDATGPGAGGA-------GESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLC 87
            ||:||           ||..|       .::.||||.|..:.:|:||:.|..:||||||||||||
Human    27 GCSSG-----------GAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLC 80

  Fly    88 YNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVML 152
            |.|||||||||:.:..:..|:|:.|:|.:.||:.:.|.:..:|:.||||.|:|....::.|.:.:
Human    81 YKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNV 145

  Fly   153 YYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAEN 217
            ||.:|:||.|||:...|...|||..|...|:|:.|..:.:.:.     ..|...:..||||
Human   146 YYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNV-----SNYSHVSLQNATS---- 201

  Fly   218 NITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKV 282
                         |..|::.:.||.:|.|||..|:::..||.||..||||.:.|:.||.:|:|||
Human   202 -------------PVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKV 253

  Fly   283 VYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLI 347
            ||.||.|||::|:||.:|||||||||.||.|||.||..:|::.|||.||..||||:.:...|.|.
Human   254 VYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLT 318

  Fly   348 TLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYP 412
            .|.|||.::||||:|.:::...|..|||.||..|||::||:|:|..|.:.:|.:.|.|||||.||
Human   319 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYP 383

  Fly   413 EVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL--RQY-KIWVVLSVAIFGY 474
            :.||.:|:||:||.|||:||:.|||||||..:|::.||::|.:|.:  |.| :..::|::::..|
Human   384 KAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISY 448

  Fly   475 IGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKR-----S 533
            ..||...|..|||..||.|.|||:...|| :||.|||.|.|:|||.||.::|:.|||.|     .
Human   449 FLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIK 513

  Fly   534 WFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH-YVYPMWADAVGWIVGLLPVLVIFLVAF 597
            |        .|..:||.....|..|..::|||.||.: |.||.|...:||::.|..:|.|.|...
Human   514 W--------CWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWIC 570

  Fly   598 QEIWRAPMSLSFRDRIKHLLQPTAEWGPAGR 628
            ..:|:...:|.  ::::.|..|:.:....|:
Human   571 ITVWKTEGTLP--EKLQKLTTPSTDLKMRGK 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	240/555 (43%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		7/24 (29%)
		SLC6sbd_GAT3	49..590	CDD:212077	243/572 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820