Protein Alignment GlyT and SLC6A6

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 255/633 - (40%)
• Similarity: 354/633 - (55%)
• Gaps: 64/633 - (10%)

  Fly    45 PGAGGAGESE---HERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIA 106
            ||.....|:|   .:|..|:.:.||:||:.|..||||||||||||||.|||||||||:.|.|..:
Human   127 PGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 191

  Fly   107 GLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAP 171
            |||:.|:|:..|||.:.|.:..:.:.||||.|:|...:::.:::.:||.:|:||..:|:|.||..
Human   192 GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQK 256

  Fly   172 VLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYF 236
            .|||.:|..:|:|.:|..    |........:...:..|.||                 |..|::
Human   257 ELPWAHCNHSWNTPHCME----DTMRKNKSVWITISSTNFTS-----------------PVIEFW 300

  Fly   237 NNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRG 301
            ...||.||.||:..||:|..||.||.|.|.:.|.|:.|||:|:||||||||.||:.:|::|.|||
Human   301 ERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 365

  Fly   302 VTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIV 366
            :|||||..||.|||.||..:|.:.|||.||..||||:.:...|.:.:|.||||:..|.|:|.:::
Human   366 LTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 430

  Fly   367 AFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVM 431
            ...|..|||.:|..||||:||:|.|..||:..|.:.|.|||||.||:.||.:|:...|::|||:|
Human   431 GCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIM 495

  Fly   432 LLTLGLDSQFALMETVTTAILDRFPNL------RQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQ 490
            ||.|||||||..:|...|:::|.:|:.      |:..|..|.|::   |:.||...|..|||..|
Human   496 LLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSIS---YLLGLTMVTEGGMYVFQ 557

  Fly   491 LMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLF 554
            |.|.|||:...|| :|..||.:||||||.....:.|:.|||.|...|..:   .|..|||...:.
Human   558 LFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKY---SWAVITPVLCVG 619

  Fly   555 ILFFNWVEYKPAKYGH-YVYPMWADAVGWIVGLLPVLVIFLVAFQEIWR--APMSLSFRDRIKHL 616
            ...|:.|:|.|..|.. ||||.||..:||.:.|..:|.:.||....:.:  .|    |..|:|:|
Human   620 CFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGP----FLVRVKYL 680

  Fly   617 LQPTA--EWGPAGRPCVNLHAERYQSQNYDG--------VTNTKILIE 654
            |.|..  .|.          .||..:..|:.        |..|.|::|
Human   681 LTPREPNRWA----------VEREGATPYNSRTVMNGALVKPTHIIVE 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	236/547 (43%)
		Herpes_BLLF1	<884..1135	CDD:282904
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	242/571 (42%)