Protein Alignment GlyT and SLC6A4

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 245/620 - (39%)
• Similarity: 368/620 - (59%)
• Gaps: 72/620 - (11%)

  Fly    45 PGAGGAGESEH----------------ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGG 93
            ||||  .::.|                ||.||..:.|||||::||:|.|||||||||:||.||||
Human    53 PGAG--DDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGG 115

  Fly    94 AFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLII 158
            |||:|:|||.:..|:||.:|||:.|||...|.::::|:.||:|:|:|..:.:::..:..|||.|:
Human   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180

  Fly   159 AWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLA 223
            ||.::|:.:||...|||.:|:.:|:|..|.:|...|     |.|:   |.|:.:
Human   181 AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSED-----NITW---TLHSTS----------- 226

  Fly   224 LGALKRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFT 286
                   ||||::...||.:  |||:::.|.|...||.|:.|.:|:::..:.|||::|||||:.|
Human   227 -------PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVT 284

  Fly   287 ALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSS 351
            |.|||::|.:|.|||.|||||..|:||||.|:|::|....||.|||.||||:|.|.:|.|:..:|
Human   285 ATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFAS 349

  Fly   352 YNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVV-DQGAGLAFIVYPEVV 415
            ||||:||||:|:|:.:..|..|||.:|.|||:::|::|...|.||.:|. |.|..|.||.|.|.:
Human   350 YNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAI 414

  Fly   416 TRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWV------VLSVAIFGY 474
            ..:|.|..:|::||:||:||||||.||.:|.|.||:||.||:     :|.      ||:|.|..:
Human   415 ANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPH-----VWAKRRERFVLAVVITCF 474

  Fly   475 IGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIG-KRSWFWNF 538
            .|.|...|..|.|.::|:::||...:||.:|:.|.:.::|.||..:|..|::.|:| ...|||.
Human   475 FGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWR- 538

  Fly   539 FWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVI-FLVAFQEIWR 602
               |.|..|:|..||||:....:.....:...|.||.|:..:|:.:|....:.| ..:|::.|..
Human   539 ---ICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT 600

  Fly   603 APMSLSFRDRIKHLLQPTAEWGPAGRPC--VNLHA 635
            ..   :|::||...:.|..   |...||  :.|:|
Human   601 PG---TFKERIIKSITPET---PTEIPCGDIRLNA 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	228/550 (41%)
		Herpes_BLLF1	<884..1135	CDD:282904
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		4/7 (57%)
		5HT_transport_N	24..64	CDD:397524	5/12 (42%)
		SLC6sbd_SERT	79..615	CDD:271399	233/573 (41%)
		Interaction with RAB4A	616..624		3/10 (30%)